CRP, NT-proBNP, CK-MB, cTnT level and clinical significance in patients with acute myocardial infarction before and after PCI

• Main Authors: Yang-Zhen Zhou, Yan Li
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-07-01
• Series: Journal of Hainan Medical University
• Subjects: Acute myocardial infarction; C-reactive protein; NT-proBNP; CK-MB
• Online Access: http://www.hnykdxxb.com/PDF/201613/9.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To analyze CRP, NT-proBNP, CK-MB, cTnT level changes and clinical significance in patients with acute myocardial infarction before and after percutaneous coronary intervention (PCI). Methods: A total of 122 cases with acute myocardial infarction (study group) who were admitted in our hospital from January 2012 to December 2014 were selected and retrospectively analyzed. Meanwhile 122 cases with healthy physical examination in our hospital were selected as control group. Patients in study group were performed with PCI, and conventional elbow vein blood was collected for CRP, NT-proBNP, CK-MB, cTnT level determination within 24 h before and after PCI, and then CRP, NT-proBNP, CK-MB, cTnT level changes before and after PCI were analyzed. Results: CRP, NT-proBNP, CK-MB, cTnT levels of patients in study group were significantly higher than that in control group (P<0.05). NT-proBNP, cTnT, CRP, CK-MB levels of patients in study group were significantly reduced after PCI (P<0.05). cTnT and NT-proBNP levels of patients in study group presented proportional relations after PCI, NT-proBNP level had a certain relations with myocardial ischemia. There were significant difference in total time and total times of unstable angina pectoris, diabetes, bifurcation lesion,multi-vessel lesions and balloon dilatation between cTnT drop group&cTnT unchanged group and NT-proBNP drop group&NT-proBNP unchanged group after PCI (P<0.05). Stent length difference was statistical significant only in cTnT drop group&cTnT unchanged group (P<0.05), while difference was not statistical significant in NT-proBNP drop group&NT-proBNP unchanged group. Logistic analysis found that total time and total times of unstable angina pectoris, diabetes, bifurcation lesion, multi-vessel lesions and balloon dilatation were the relevant factors affecting postoperative cTnT and NT-proBNP level changes for patients with acute myocardial infarction, and stent length was the relevant factor affecting cTnT level changes. There was significant difference in heart adverse event occurrence rate in cTnT drop group and NT-proBNP drop group or between cTnT unchanged group and NTproBNP unchanged group (P<0.05). Conclusions: CRP, NT-proBNP, CK-MB, cTnT levels of patients with acute myocardial infarction are significantly higher than that of healthy people, and cTnT and NT-proBNP levels are valuable in prediction of heart adverse event occurrence rate after PCI.