Covariates of corticotropin-releasing hormone (CRH) concentrations in cerebrospinal fluid (CSF) from healthy humans

• Main Authors: Whalen Gail, Maibach Hilda, Baraniuk James N, Clauw Daniel J
• Format: Article
• Language: English
• Published: BMC 2004-12-01
• Series: BMC Neuroscience
• Online Access: http://www.biomedcentral.com/1471-2202/5/58

<p>Abstract</p> <p>Background</p> <p>Define covariates of cerebrospinal corticotropin-releasing hormone (CRH) levels in normal humans. CRH_CSFwas measured in 9 normal subjects as part of an intensive study of physiological responses stressors in chronic pain and fatigue states. CRH_CSFwas first correlated with demographic, vital sign, HPA axis, validated questionnaire domains, baseline and maximal responses to pain, exercise and other stressors. Significant factors were used for linear regression modeling.</p> <p>Results</p> <p>Highly significant correlations were found despite the small number of subjects. Three models were defined: (a) CRH_CSFwith blood glucose and sodium (explained variance = 0.979, adjusted R²= 0.958, p = 0.02 by 2-tailed testing); (b) CRH_CSFwith resting respiratory and heart rates (R²= 0.963, adjusted R²= 0.939, p = 0.007); and (c) CRH_CSFwith SF-36 Vitality and Multidimensional Fatigue Inventory Physical Fatigue domains (R²= 0.859, adjusted R²= 0.789, p = 0.02).</p> <p>Conclusions</p> <p>Low CRH_CSFwas predicted by lower glucose, respiratory and heart rates, and higher sodium and psychometric constructs of well being. Responses at peak exercise and to other acute stressors were not correlated. CRH_CSFmay have reflected an overall, or chronic, set-point for physiological responses, but did not predict the reserves available to respond to immediate stressors.</p>