Palytoxin and an Ostreopsis toxin extract increase the levels of mRNAs encoding inflammation-related proteins in human macrophages via p38 MAPK and NF-κB.

Palytoxin and an Ostreopsis toxin extract increase the levels of mRNAs encoding inflammation-related proteins in human macrophages via p38 MAPK and NF-κB.

Palytoxin and, likely, its analogues produced by the dinoflagellate genus Ostreopsis, represent a class of non-proteinaceous compounds displaying high toxicity in animals. Owing to the wide distribution and the poisonous effects of these toxins in humans, their chemistry and mechanism of action have...

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Bibliographic Details
Main Authors: Rita Crinelli, Elisa Carloni, Elisa Giacomini, Antonella Penna, Sabrina Dominici, Cecilia Battocchi, Patrizia Ciminiello, Carmela Dell'Aversano, Ernesto Fattorusso, Martino Forino, Luciana Tartaglione, Mauro Magnani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3365899?pdf=render

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http://europepmc.org/articles/PMC3365899?pdf=render

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