Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides

Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides

2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for theirantitumor activity. The structures of these compounds were established by 1H and 13C-NMR spectroscopy. Glucoside 3b shows an in vitro IC50 value of 16.4 μM againstproliferation of the human promyelotic leukemia (HL60) cell lin...

Full description

Bibliographic Details
Main Authors: Hussein F.. Zohdi, Ayman M. Saleh, Ibrahim M. Abdou
Format: Article
Language:English
Published: MDPI AG 2004-02-01
Series:Molecules
Subjects:
Trifluoromethylpyrazole
glucopyranose
antitumor agents.
Online Access:http://www.mdpi.com/1420-3049/9/3/109/
Description
Summary:2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for theirantitumor activity. The structures of these compounds were established by 1H and 13C-NMR spectroscopy. Glucoside 3b shows an in vitro IC50 value of 16.4 μM againstproliferation of the human promyelotic leukemia (HL60) cell line.
ISSN:1420-3049

Similar Items