V2a interneuron diversity tailors spinal circuit organization to control the vigor of locomotor movements

V2a interneuron diversity tailors spinal circuit organization to control the vigor of locomotor movements

Locomotor circuits in the spinal cord produce precise movements with variations in timing and vigor. Here, the authors report that such motor flexibility is generated through the specificity of connections between subtypes of V2a interneurons and motoneuron populations and their distinct plasticity...

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Main Authors: Jianren Song, Elin Dahlberg, Abdeljabbar El Manira
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05827-9
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spelling doaj-c2e86865363741b69ea95833620b6b632021-05-11T10:32:31ZengNature Publishing GroupNature Communications2041-17232018-08-019111410.1038/s41467-018-05827-9V2a interneuron diversity tailors spinal circuit organization to control the vigor of locomotor movementsJianren Song0Elin Dahlberg1Abdeljabbar El Manira2Center of Translational Medicine, Tongji Hospital, Tongji University School of MedicineDepartment of Neuroscience, Karolinska InstituteDepartment of Neuroscience, Karolinska InstituteLocomotor circuits in the spinal cord produce precise movements with variations in timing and vigor. Here, the authors report that such motor flexibility is generated through the specificity of connections between subtypes of V2a interneurons and motoneuron populations and their distinct plasticity mechanisms.https://doi.org/10.1038/s41467-018-05827-9
collection DOAJ
language English
format Article
sources DOAJ
author Jianren Song
Elin Dahlberg
Abdeljabbar El Manira
spellingShingle Jianren Song
Elin Dahlberg
Abdeljabbar El Manira
V2a interneuron diversity tailors spinal circuit organization to control the vigor of locomotor movements
Nature Communications
author_facet Jianren Song
Elin Dahlberg
Abdeljabbar El Manira
author_sort Jianren Song
title V2a interneuron diversity tailors spinal circuit organization to control the vigor of locomotor movements
title_short V2a interneuron diversity tailors spinal circuit organization to control the vigor of locomotor movements
title_full V2a interneuron diversity tailors spinal circuit organization to control the vigor of locomotor movements
title_fullStr V2a interneuron diversity tailors spinal circuit organization to control the vigor of locomotor movements
title_full_unstemmed V2a interneuron diversity tailors spinal circuit organization to control the vigor of locomotor movements
title_sort v2a interneuron diversity tailors spinal circuit organization to control the vigor of locomotor movements
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-08-01
description Locomotor circuits in the spinal cord produce precise movements with variations in timing and vigor. Here, the authors report that such motor flexibility is generated through the specificity of connections between subtypes of V2a interneurons and motoneuron populations and their distinct plasticity mechanisms.
url https://doi.org/10.1038/s41467-018-05827-9
work_keys_str_mv AT jianrensong v2ainterneurondiversitytailorsspinalcircuitorganizationtocontrolthevigoroflocomotormovements
AT elindahlberg v2ainterneurondiversitytailorsspinalcircuitorganizationtocontrolthevigoroflocomotormovements
AT abdeljabbarelmanira v2ainterneurondiversitytailorsspinalcircuitorganizationtocontrolthevigoroflocomotormovements
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