Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia

We tested the hypothesis that, in acute metabolic acidemia, the fetal left ventricle (LV) has the capacity to increase its contractility in response to angiotensin II infusion. Eleven ewes and their fetuses were instrumented at 127–138/145 days of gestation. The effect of angiotensin II on fetal LV...

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Main Authors: Ganesh Acharya, James C. Huhta, Mervi Haapsamo, Ole-Jakob How, Tiina Erkinaro, Juha Räsänen
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Journal of Pregnancy
Online Access:http://dx.doi.org/10.1155/2011/634240
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spelling doaj-c2e76253fc74431c969183336431d5a42020-11-25T01:05:56ZengHindawi LimitedJournal of Pregnancy2090-27272090-27352011-01-01201110.1155/2011/634240634240Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic AcidemiaGanesh Acharya0James C. Huhta1Mervi Haapsamo2Ole-Jakob How3Tiina Erkinaro4Juha Räsänen5Women's Health and Perinatology Research Group, Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø and Department of Obstetrics and Gynecology, University Hospital of Northern Norway, 9038 Tromsø, NorwayWomen's Health and Perinatology Research Group, Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø and Department of Obstetrics and Gynecology, University Hospital of Northern Norway, 9038 Tromsø, NorwayDepartment of Obstetrics and Gynecology, Oulu University Hospital, 90014 Oulu, FinlandCardiovascular Research Group, Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, NorwayDepartment of Anesthesiology, Oulu University Hospital, 90220 Oulu, FinlandDepartment of Obstetrics and Gynecology, Oulu University Hospital, 90014 Oulu, FinlandWe tested the hypothesis that, in acute metabolic acidemia, the fetal left ventricle (LV) has the capacity to increase its contractility in response to angiotensin II infusion. Eleven ewes and their fetuses were instrumented at 127–138/145 days of gestation. The effect of angiotensin II on fetal LV function was assessed using intraventricular pressure catheter and tissue Doppler imaging (TDI). Angiotensin II increased fetal arterial blood pressure, whereas pH and pO2 decreased. The heart rate and systemic venous pressure were not affected significantly. The LV end-diastolic and end-systolic pressures, as well as dP/dtmax, increased. The TDI-derived LV longitudinal myocardial isovolumic contraction velocity and its acceleration and velocity during early filling were higher than those at baseline. The incidence of absent isovolumic relaxation velocity was greater during angiotensin II infusion. In summary, during acute metabolic acidemia, the fetal left ventricle could increase its contractility in response to inotropic stimulus even in the presence of increased afterload. The diastolic LV function parameters were altered by angiotensin II.http://dx.doi.org/10.1155/2011/634240
collection DOAJ
language English
format Article
sources DOAJ
author Ganesh Acharya
James C. Huhta
Mervi Haapsamo
Ole-Jakob How
Tiina Erkinaro
Juha Räsänen
spellingShingle Ganesh Acharya
James C. Huhta
Mervi Haapsamo
Ole-Jakob How
Tiina Erkinaro
Juha Räsänen
Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia
Journal of Pregnancy
author_facet Ganesh Acharya
James C. Huhta
Mervi Haapsamo
Ole-Jakob How
Tiina Erkinaro
Juha Räsänen
author_sort Ganesh Acharya
title Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia
title_short Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia
title_full Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia
title_fullStr Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia
title_full_unstemmed Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia
title_sort effect of angiotensin ii on the left ventricular function in a near-term fetal sheep with metabolic acidemia
publisher Hindawi Limited
series Journal of Pregnancy
issn 2090-2727
2090-2735
publishDate 2011-01-01
description We tested the hypothesis that, in acute metabolic acidemia, the fetal left ventricle (LV) has the capacity to increase its contractility in response to angiotensin II infusion. Eleven ewes and their fetuses were instrumented at 127–138/145 days of gestation. The effect of angiotensin II on fetal LV function was assessed using intraventricular pressure catheter and tissue Doppler imaging (TDI). Angiotensin II increased fetal arterial blood pressure, whereas pH and pO2 decreased. The heart rate and systemic venous pressure were not affected significantly. The LV end-diastolic and end-systolic pressures, as well as dP/dtmax, increased. The TDI-derived LV longitudinal myocardial isovolumic contraction velocity and its acceleration and velocity during early filling were higher than those at baseline. The incidence of absent isovolumic relaxation velocity was greater during angiotensin II infusion. In summary, during acute metabolic acidemia, the fetal left ventricle could increase its contractility in response to inotropic stimulus even in the presence of increased afterload. The diastolic LV function parameters were altered by angiotensin II.
url http://dx.doi.org/10.1155/2011/634240
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