Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia
We tested the hypothesis that, in acute metabolic acidemia, the fetal left ventricle (LV) has the capacity to increase its contractility in response to angiotensin II infusion. Eleven ewes and their fetuses were instrumented at 127–138/145 days of gestation. The effect of angiotensin II on fetal LV...
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Online Access: | http://dx.doi.org/10.1155/2011/634240 |
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doaj-c2e76253fc74431c969183336431d5a42020-11-25T01:05:56ZengHindawi LimitedJournal of Pregnancy2090-27272090-27352011-01-01201110.1155/2011/634240634240Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic AcidemiaGanesh Acharya0James C. Huhta1Mervi Haapsamo2Ole-Jakob How3Tiina Erkinaro4Juha Räsänen5Women's Health and Perinatology Research Group, Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø and Department of Obstetrics and Gynecology, University Hospital of Northern Norway, 9038 Tromsø, NorwayWomen's Health and Perinatology Research Group, Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø and Department of Obstetrics and Gynecology, University Hospital of Northern Norway, 9038 Tromsø, NorwayDepartment of Obstetrics and Gynecology, Oulu University Hospital, 90014 Oulu, FinlandCardiovascular Research Group, Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, NorwayDepartment of Anesthesiology, Oulu University Hospital, 90220 Oulu, FinlandDepartment of Obstetrics and Gynecology, Oulu University Hospital, 90014 Oulu, FinlandWe tested the hypothesis that, in acute metabolic acidemia, the fetal left ventricle (LV) has the capacity to increase its contractility in response to angiotensin II infusion. Eleven ewes and their fetuses were instrumented at 127–138/145 days of gestation. The effect of angiotensin II on fetal LV function was assessed using intraventricular pressure catheter and tissue Doppler imaging (TDI). Angiotensin II increased fetal arterial blood pressure, whereas pH and pO2 decreased. The heart rate and systemic venous pressure were not affected significantly. The LV end-diastolic and end-systolic pressures, as well as dP/dtmax, increased. The TDI-derived LV longitudinal myocardial isovolumic contraction velocity and its acceleration and velocity during early filling were higher than those at baseline. The incidence of absent isovolumic relaxation velocity was greater during angiotensin II infusion. In summary, during acute metabolic acidemia, the fetal left ventricle could increase its contractility in response to inotropic stimulus even in the presence of increased afterload. The diastolic LV function parameters were altered by angiotensin II.http://dx.doi.org/10.1155/2011/634240 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ganesh Acharya James C. Huhta Mervi Haapsamo Ole-Jakob How Tiina Erkinaro Juha Räsänen |
spellingShingle |
Ganesh Acharya James C. Huhta Mervi Haapsamo Ole-Jakob How Tiina Erkinaro Juha Räsänen Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia Journal of Pregnancy |
author_facet |
Ganesh Acharya James C. Huhta Mervi Haapsamo Ole-Jakob How Tiina Erkinaro Juha Räsänen |
author_sort |
Ganesh Acharya |
title |
Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia |
title_short |
Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia |
title_full |
Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia |
title_fullStr |
Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia |
title_full_unstemmed |
Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia |
title_sort |
effect of angiotensin ii on the left ventricular function in a near-term fetal sheep with metabolic acidemia |
publisher |
Hindawi Limited |
series |
Journal of Pregnancy |
issn |
2090-2727 2090-2735 |
publishDate |
2011-01-01 |
description |
We tested the hypothesis that, in acute metabolic acidemia, the fetal left ventricle (LV) has the capacity to increase its contractility in response to angiotensin II infusion. Eleven ewes and their fetuses were instrumented at 127–138/145 days of gestation. The effect of angiotensin II on fetal LV function was assessed using intraventricular pressure catheter and tissue Doppler imaging (TDI). Angiotensin II increased fetal arterial blood pressure, whereas pH and pO2 decreased. The heart rate and systemic venous pressure were not affected significantly. The LV end-diastolic and end-systolic pressures, as well as dP/dtmax, increased. The TDI-derived LV longitudinal myocardial isovolumic contraction velocity and its acceleration and velocity during early filling were higher than those at baseline. The incidence of absent isovolumic relaxation velocity was greater during angiotensin II infusion. In summary, during acute metabolic acidemia, the fetal left ventricle could increase its contractility in response to inotropic stimulus even in the presence of increased afterload. The diastolic LV function parameters were altered by angiotensin II. |
url |
http://dx.doi.org/10.1155/2011/634240 |
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