Global profiling of protein–DNA and protein–nucleosome binding affinities using quantitative mass spectrometry

Global profiling of protein–DNA and protein–nucleosome binding affinities using quantitative mass spectrometry

Quantitative mass spectrometry enables the proteome-wide assessment of biomolecular binding affinities. While previous approaches mainly focused on protein–small molecule interactions, the authors here present a method to probe protein–DNA and protein–nucleosome binding affinities at proteome scale....

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Bibliographic Details
Main Authors: Matthew M. Makowski, Cathrin Gräwe, Benjamin M. Foster, Nhuong V. Nguyen, Till Bartke, Michiel Vermeulen
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04084-0
Description
Summary:Quantitative mass spectrometry enables the proteome-wide assessment of biomolecular binding affinities. While previous approaches mainly focused on protein–small molecule interactions, the authors here present a method to probe protein–DNA and protein–nucleosome binding affinities at proteome scale.
ISSN:2041-1723

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