Osteoclasts and CD8 T Cells Form a Negative Feedback Loop That Contributes to Homeostasis of Both the Skeletal and Immune Systems

Osteoclasts and CD8 T Cells Form a Negative Feedback Loop That Contributes to Homeostasis of Both the Skeletal and Immune Systems

There are a number of dynamic regulatory loops that maintain homeostasis of the immune and skeletal systems. In this review, we highlight a number of these regulatory interactions that contribute to maintaining homeostasis. In addition, we review data on a negative regulatory feedback loop between o...

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Main Authors: Zachary S. Buchwald, Rajeev Aurora
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Clinical and Developmental Immunology
Online Access:http://dx.doi.org/10.1155/2013/429373
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spelling doaj-c2ddc80fb37d47fa97ddaae15a7f714d2020-11-24T22:53:40ZengHindawi LimitedClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/429373429373Osteoclasts and CD8 T Cells Form a Negative Feedback Loop That Contributes to Homeostasis of Both the Skeletal and Immune SystemsZachary S. Buchwald0Rajeev Aurora1Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 S. Grand Boulevond DRC 605, St. Louis, MO 63104, USADepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 S. Grand Boulevond DRC 605, St. Louis, MO 63104, USAThere are a number of dynamic regulatory loops that maintain homeostasis of the immune and skeletal systems. In this review, we highlight a number of these regulatory interactions that contribute to maintaining homeostasis. In addition, we review data on a negative regulatory feedback loop between osteoclasts and CD8 T cells that contributes to homeostasis of both the skeletal and immune systems.http://dx.doi.org/10.1155/2013/429373
collection DOAJ
language English
format Article
sources DOAJ
author Zachary S. Buchwald
Rajeev Aurora
spellingShingle Zachary S. Buchwald
Rajeev Aurora
Osteoclasts and CD8 T Cells Form a Negative Feedback Loop That Contributes to Homeostasis of Both the Skeletal and Immune Systems
Clinical and Developmental Immunology
author_facet Zachary S. Buchwald
Rajeev Aurora
author_sort Zachary S. Buchwald
title Osteoclasts and CD8 T Cells Form a Negative Feedback Loop That Contributes to Homeostasis of Both the Skeletal and Immune Systems
title_short Osteoclasts and CD8 T Cells Form a Negative Feedback Loop That Contributes to Homeostasis of Both the Skeletal and Immune Systems
title_full Osteoclasts and CD8 T Cells Form a Negative Feedback Loop That Contributes to Homeostasis of Both the Skeletal and Immune Systems
title_fullStr Osteoclasts and CD8 T Cells Form a Negative Feedback Loop That Contributes to Homeostasis of Both the Skeletal and Immune Systems
title_full_unstemmed Osteoclasts and CD8 T Cells Form a Negative Feedback Loop That Contributes to Homeostasis of Both the Skeletal and Immune Systems
title_sort osteoclasts and cd8 t cells form a negative feedback loop that contributes to homeostasis of both the skeletal and immune systems
publisher Hindawi Limited
series Clinical and Developmental Immunology
issn 1740-2522
1740-2530
publishDate 2013-01-01
description There are a number of dynamic regulatory loops that maintain homeostasis of the immune and skeletal systems. In this review, we highlight a number of these regulatory interactions that contribute to maintaining homeostasis. In addition, we review data on a negative regulatory feedback loop between osteoclasts and CD8 T cells that contributes to homeostasis of both the skeletal and immune systems.
url http://dx.doi.org/10.1155/2013/429373
work_keys_str_mv AT zacharysbuchwald osteoclastsandcd8tcellsformanegativefeedbackloopthatcontributestohomeostasisofboththeskeletalandimmunesystems
AT rajeevaurora osteoclastsandcd8tcellsformanegativefeedbackloopthatcontributestohomeostasisofboththeskeletalandimmunesystems
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