Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology

Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology

An actin cap protects the morphology of the nucleus during cellular mechanical stress. Here, the authors show that the nuclear lamina protein lamin A/C mediates the formation of the actin cap in response to stress, and model the distribution of forces in the presence and absence of the actin cap.

Bibliographic Details
Main Authors: Jeong-Ki Kim, Arghavan Louhghalam, Geonhui Lee, Benjamin W. Schafer, Denis Wirtz, Dong-Hwee Kim
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02217-5
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spelling doaj-c2db46571a9e4e98b6c92809cc4d07ae2021-05-11T07:22:04ZengNature Publishing GroupNature Communications2041-17232017-12-018111310.1038/s41467-017-02217-5Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphologyJeong-Ki Kim0Arghavan Louhghalam1Geonhui Lee2Benjamin W. Schafer3Denis Wirtz4Dong-Hwee Kim5KU-KIST Graduate School of Converging Science and Technology, Korea UniversityDepartment of Civil and Environmental Engineering, University of Massachusetts DartmouthKU-KIST Graduate School of Converging Science and Technology, Korea UniversityInstitute for NanoBioTechnology, The Johns Hopkins UniversityInstitute for NanoBioTechnology, The Johns Hopkins UniversityKU-KIST Graduate School of Converging Science and Technology, Korea UniversityAn actin cap protects the morphology of the nucleus during cellular mechanical stress. Here, the authors show that the nuclear lamina protein lamin A/C mediates the formation of the actin cap in response to stress, and model the distribution of forces in the presence and absence of the actin cap.https://doi.org/10.1038/s41467-017-02217-5
collection DOAJ
language English
format Article
sources DOAJ
author Jeong-Ki Kim
Arghavan Louhghalam
Geonhui Lee
Benjamin W. Schafer
Denis Wirtz
Dong-Hwee Kim
spellingShingle Jeong-Ki Kim
Arghavan Louhghalam
Geonhui Lee
Benjamin W. Schafer
Denis Wirtz
Dong-Hwee Kim
Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology
Nature Communications
author_facet Jeong-Ki Kim
Arghavan Louhghalam
Geonhui Lee
Benjamin W. Schafer
Denis Wirtz
Dong-Hwee Kim
author_sort Jeong-Ki Kim
title Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology
title_short Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology
title_full Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology
title_fullStr Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology
title_full_unstemmed Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology
title_sort nuclear lamin a/c harnesses the perinuclear apical actin cables to protect nuclear morphology
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-12-01
description An actin cap protects the morphology of the nucleus during cellular mechanical stress. Here, the authors show that the nuclear lamina protein lamin A/C mediates the formation of the actin cap in response to stress, and model the distribution of forces in the presence and absence of the actin cap.
url https://doi.org/10.1038/s41467-017-02217-5
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AT arghavanlouhghalam nuclearlaminacharnessestheperinuclearapicalactincablestoprotectnuclearmorphology
AT geonhuilee nuclearlaminacharnessestheperinuclearapicalactincablestoprotectnuclearmorphology
AT benjaminwschafer nuclearlaminacharnessestheperinuclearapicalactincablestoprotectnuclearmorphology
AT deniswirtz nuclearlaminacharnessestheperinuclearapicalactincablestoprotectnuclearmorphology
AT donghweekim nuclearlaminacharnessestheperinuclearapicalactincablestoprotectnuclearmorphology
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