Synthesis and In Vitro Antioxidant Evaluation of New 1,3,5-Tri-{2-methoxy-4-[(4,5-dihydro-1H-1,2,4-triazol-5-on-4-yl)-azomethine]-phenoxycarbonyl}-Benzene Derivatives

Synthesis and In Vitro Antioxidant Evaluation of New 1,3,5-Tri-{2-methoxy-4-[(4,5-dihydro-1H-1,2,4-triazol-5-on-4-yl)-azomethine]-phenoxycarbonyl}-Benzene Derivatives

Nine new 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives were synthesized and characterized by elemental analyses and IR, 1H-NMR, 13C-NMR and UV spectral data. The synthesized compounds were analyzed for their in vitro potential antioxidant activities in three different methods. Those antioxidant act...

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Main Authors: H. Yuksek, O. Akyildirim, O. Gursoy Kol
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2013/517420
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spelling doaj-c2d76f5a52ec42dc865e2962835319512020-11-24T22:37:18ZengHindawi LimitedJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/517420517420Synthesis and In Vitro Antioxidant Evaluation of New 1,3,5-Tri-{2-methoxy-4-[(4,5-dihydro-1H-1,2,4-triazol-5-on-4-yl)-azomethine]-phenoxycarbonyl}-Benzene DerivativesH. Yuksek0O. Akyildirim1O. Gursoy Kol2Department of Chemistry, Kafkas University, 36100 Kars, TurkeyDepartment of Chemistry, Kafkas University, 36100 Kars, TurkeyDepartment of Chemistry, Kafkas University, 36100 Kars, TurkeyNine new 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives were synthesized and characterized by elemental analyses and IR, 1H-NMR, 13C-NMR and UV spectral data. The synthesized compounds were analyzed for their in vitro potential antioxidant activities in three different methods. Those antioxidant activities were compared to standard antioxidants such as BHA, BHT and α-tocopherol. Compounds 4e, 5a and 5d showed best activity for iron binding. In addition, the compounds 4 were titrated potentiometrically with tetrabutylammonium hydroxide (TBAH) in four non-aqueous solvents (isopropyl alcohol, tert-butyl alcohol, acetone and N,N-dimethyl formamide). Thus, the half-neutralization potential values and the corresponding pKa values were determined in all cases.http://dx.doi.org/10.1155/2013/517420
collection DOAJ
language English
format Article
sources DOAJ
author H. Yuksek
O. Akyildirim
O. Gursoy Kol
spellingShingle H. Yuksek
O. Akyildirim
O. Gursoy Kol
Synthesis and In Vitro Antioxidant Evaluation of New 1,3,5-Tri-{2-methoxy-4-[(4,5-dihydro-1H-1,2,4-triazol-5-on-4-yl)-azomethine]-phenoxycarbonyl}-Benzene Derivatives
Journal of Chemistry
author_facet H. Yuksek
O. Akyildirim
O. Gursoy Kol
author_sort H. Yuksek
title Synthesis and In Vitro Antioxidant Evaluation of New 1,3,5-Tri-{2-methoxy-4-[(4,5-dihydro-1H-1,2,4-triazol-5-on-4-yl)-azomethine]-phenoxycarbonyl}-Benzene Derivatives
title_short Synthesis and In Vitro Antioxidant Evaluation of New 1,3,5-Tri-{2-methoxy-4-[(4,5-dihydro-1H-1,2,4-triazol-5-on-4-yl)-azomethine]-phenoxycarbonyl}-Benzene Derivatives
title_full Synthesis and In Vitro Antioxidant Evaluation of New 1,3,5-Tri-{2-methoxy-4-[(4,5-dihydro-1H-1,2,4-triazol-5-on-4-yl)-azomethine]-phenoxycarbonyl}-Benzene Derivatives
title_fullStr Synthesis and In Vitro Antioxidant Evaluation of New 1,3,5-Tri-{2-methoxy-4-[(4,5-dihydro-1H-1,2,4-triazol-5-on-4-yl)-azomethine]-phenoxycarbonyl}-Benzene Derivatives
title_full_unstemmed Synthesis and In Vitro Antioxidant Evaluation of New 1,3,5-Tri-{2-methoxy-4-[(4,5-dihydro-1H-1,2,4-triazol-5-on-4-yl)-azomethine]-phenoxycarbonyl}-Benzene Derivatives
title_sort synthesis and in vitro antioxidant evaluation of new 1,3,5-tri-{2-methoxy-4-[(4,5-dihydro-1h-1,2,4-triazol-5-on-4-yl)-azomethine]-phenoxycarbonyl}-benzene derivatives
publisher Hindawi Limited
series Journal of Chemistry
issn 2090-9063
2090-9071
publishDate 2013-01-01
description Nine new 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives were synthesized and characterized by elemental analyses and IR, 1H-NMR, 13C-NMR and UV spectral data. The synthesized compounds were analyzed for their in vitro potential antioxidant activities in three different methods. Those antioxidant activities were compared to standard antioxidants such as BHA, BHT and α-tocopherol. Compounds 4e, 5a and 5d showed best activity for iron binding. In addition, the compounds 4 were titrated potentiometrically with tetrabutylammonium hydroxide (TBAH) in four non-aqueous solvents (isopropyl alcohol, tert-butyl alcohol, acetone and N,N-dimethyl formamide). Thus, the half-neutralization potential values and the corresponding pKa values were determined in all cases.
url http://dx.doi.org/10.1155/2013/517420
work_keys_str_mv AT hyuksek synthesisandinvitroantioxidantevaluationofnew135tri2methoxy445dihydro1h124triazol5on4ylazomethinephenoxycarbonylbenzenederivatives
AT oakyildirim synthesisandinvitroantioxidantevaluationofnew135tri2methoxy445dihydro1h124triazol5on4ylazomethinephenoxycarbonylbenzenederivatives
AT ogursoykol synthesisandinvitroantioxidantevaluationofnew135tri2methoxy445dihydro1h124triazol5on4ylazomethinephenoxycarbonylbenzenederivatives
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