Generation of induced pluripotent stem cells (NIMHi002-A and NIMHi003-A) from two sporadic Parkinson's disease patient of East Indian ethnicity

Generation of induced pluripotent stem cells (NIMHi002-A and NIMHi003-A) from two sporadic Parkinson's disease patient of East Indian ethnicity

Epidemiological studies suggest that about 95% of PD have a sporadic component. We have generated induced pluripotent stem cells (iPSCs) using Sendai-virus reprogramming-method from peripheral blood mononuclear cells of two sporadic PD-patient of East-Indian ethnicity carrying no PD-related gene mut...

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Main Authors: Indrani Datta, Soham Jagtap, Sowmithra, Ravi Yadav, Pramod Kumar Pal
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506120302968
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spelling doaj-c2d6d6bf2f554eeabc55b635dca8f77b2020-12-19T05:04:44ZengElsevierStem Cell Research1873-50612020-12-0149101995Generation of induced pluripotent stem cells (NIMHi002-A and NIMHi003-A) from two sporadic Parkinson's disease patient of East Indian ethnicityIndrani Datta0Soham Jagtap1 Sowmithra2Ravi Yadav3Pramod Kumar Pal4Department of Biophysics, National Institute of Mental Health and Neurosciences, Bengaluru 560029, India; Corresponding author at: Department of Biophysics, National Institute of Mental Health and Neurosciences, P.B. No – 2900, Hosur Road, Bengaluru 560029, Karnataka, India.Department of Biophysics, National Institute of Mental Health and Neurosciences, Bengaluru 560029, IndiaDepartment of Biophysics, National Institute of Mental Health and Neurosciences, Bengaluru 560029, IndiaDepartment of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru 560029, Karnataka, IndiaDepartment of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru 560029, Karnataka, IndiaEpidemiological studies suggest that about 95% of PD have a sporadic component. We have generated induced pluripotent stem cells (iPSCs) using Sendai-virus reprogramming-method from peripheral blood mononuclear cells of two sporadic PD-patient of East-Indian ethnicity carrying no PD-related gene mutations. PD diagnosis was performed using Unified Parkinson's Disease rating scale (UPDRS) score and confirmed by [18F]fluoro-L-dopa [F-DOPA] positron emission tomography (F-DOPA PET). The iPSC lines were characterized for self-renewal and pluripotency. These generated lines will provide a valuable resource to understand the pathophysiology of this disease and a drug-screening platform.http://www.sciencedirect.com/science/article/pii/S1873506120302968
collection DOAJ
language English
format Article
sources DOAJ
author Indrani Datta
Soham Jagtap
Sowmithra
Ravi Yadav
Pramod Kumar Pal
spellingShingle Indrani Datta
Soham Jagtap
Sowmithra
Ravi Yadav
Pramod Kumar Pal
Generation of induced pluripotent stem cells (NIMHi002-A and NIMHi003-A) from two sporadic Parkinson's disease patient of East Indian ethnicity
Stem Cell Research
author_facet Indrani Datta
Soham Jagtap
Sowmithra
Ravi Yadav
Pramod Kumar Pal
author_sort Indrani Datta
title Generation of induced pluripotent stem cells (NIMHi002-A and NIMHi003-A) from two sporadic Parkinson's disease patient of East Indian ethnicity
title_short Generation of induced pluripotent stem cells (NIMHi002-A and NIMHi003-A) from two sporadic Parkinson's disease patient of East Indian ethnicity
title_full Generation of induced pluripotent stem cells (NIMHi002-A and NIMHi003-A) from two sporadic Parkinson's disease patient of East Indian ethnicity
title_fullStr Generation of induced pluripotent stem cells (NIMHi002-A and NIMHi003-A) from two sporadic Parkinson's disease patient of East Indian ethnicity
title_full_unstemmed Generation of induced pluripotent stem cells (NIMHi002-A and NIMHi003-A) from two sporadic Parkinson's disease patient of East Indian ethnicity
title_sort generation of induced pluripotent stem cells (nimhi002-a and nimhi003-a) from two sporadic parkinson's disease patient of east indian ethnicity
publisher Elsevier
series Stem Cell Research
issn 1873-5061
publishDate 2020-12-01
description Epidemiological studies suggest that about 95% of PD have a sporadic component. We have generated induced pluripotent stem cells (iPSCs) using Sendai-virus reprogramming-method from peripheral blood mononuclear cells of two sporadic PD-patient of East-Indian ethnicity carrying no PD-related gene mutations. PD diagnosis was performed using Unified Parkinson's Disease rating scale (UPDRS) score and confirmed by [18F]fluoro-L-dopa [F-DOPA] positron emission tomography (F-DOPA PET). The iPSC lines were characterized for self-renewal and pluripotency. These generated lines will provide a valuable resource to understand the pathophysiology of this disease and a drug-screening platform.
url http://www.sciencedirect.com/science/article/pii/S1873506120302968
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