The Use of Upconversion Nanoparticles in Prostate Cancer Photodynamic Therapy

• Main Authors: Michał Osuchowski, Filip Osuchowski, Wojciech Latos, Aleksandra Kawczyk-Krupka
• Format: Article
• Language: English
• Published: MDPI AG 2021-04-01
• Series: Life
• Subjects: upconversion nanoparticles; UCNPs; prostate cancer; photodynamic therapy; PDT
• Online Access: https://www.mdpi.com/2075-1729/11/4/360

Photodynamic Therapy (PDT) is a cancer treatment that uses light, a photosensitizer, and oxygen to destroy tumors. This article is a review of approaches to the treatment of prostate cancer applying upconversion nanoparticles (UCNPs). UCNPs have become a phenomenon that are rapidly gaining recognition in medicine. They have proven to be highly selective and specific and present a powerful tool in the diagnosis and treatment of prostate cancer. Prostate cancer is a huge health problem in Western countries. Its early detection can significantly improve patients’ prognosis, but currently used diagnostic methods leave much to be desired. Recently developed methodologies regarding UCNP research between the years 2021 and 2014 for prostate cancer PDT will also be discussed. Current limitations in PDT include tissue irradiation with visible wavelengths that have a short tissue penetration depth. PDT with the objectives to synthesize UCNPs composed of a lanthanide core with a coating of adsorbed dye that will generate fluorescence after excitation with near-infrared light to illuminate deep tissue is a subject of intense research in prostate cancer.