Improved Synthesis of β-D-6-Methylpurine Riboside and Antitumor Effects of the β-D- and α-D-Anomers

Improved Synthesis of β-D-6-Methylpurine Riboside and Antitumor Effects of the β-D- and α-D-Anomers

6-Methylpurine-β-D-riboside (β-D-MPR) has been synthesized by coupling6-methylpurine and 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribose using conditions that producethe β-D-anomer exclusively. The in vitro antitumor effects of β-D-MPR and 6-methyl-purine-α-D-riboside (α-D-MPR) in five hum...

Full description

Bibliographic Details
Main Authors: J. Sufrin, R. Bernacki, A. Spiess, P. Pera, C. Marasco
Format: Article
Language:English
Published: MDPI AG 2005-08-01
Series:Molecules
Subjects:
6-Methylpurine-β-D-riboside
6-methylpurine-α-D-riboside
antitumor activity
synthesis
Online Access:http://www.mdpi.com/1420-3049/10/8/1015/

Internet

http://www.mdpi.com/1420-3049/10/8/1015/

Similar Items