A Robust Model System for Retinal Hypoxia: Live Imaging of Calcium Dynamics and Gene Expression Studies in Primary Human Mixed Retinal Culture

A Robust Model System for Retinal Hypoxia: Live Imaging of Calcium Dynamics and Gene Expression Studies in Primary Human Mixed Retinal Culture

The detailed mechanisms underlying oxidative stress that leads to neuroinflammation and neurodegeneration in retinal vascular conditions, including diabetic retinopathy, retinopathy of prematurity etc., remain largely unexplored mainly due to a lack of suitable disease models that can simulate the i...

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Bibliographic Details
Main Authors: Shahna Shahulhameed, Sarpras Swain, Soumya Jana, Jay Chhablani, Mohammad Javed Ali, Rajeev R. Pappuru, Mudit Tyagi, Sushma Vishwakarma, Nanda Sailaja, Subhabrata Chakrabarti, Lopamudra Giri, Inderjeet Kaur
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Neuroscience
Subjects:
retina
glia
calcium spiking
neurons
hypoxia
neurodegeneration
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01445/full

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