A clinical trial of the efficacy of a combination of antiseptic and antimicrobial agent in the treatment of inflammatory processes of the skin and soft tissue

• Main Author: Arsen Yurievich Grigoryan
• Format: Article
• Language: Russian
• Published: QUASAR, LLC 2021-06-01
• Series: Issledovaniâ i Praktika v Medicine
• Subjects: purulent-inflammatory process; purulent wound; local treatment of wounds; miramistin; metronidazole; sodium salt of carboxymethylcellulose; wound process; wound healing; ph-metry; leukocyte index; wound planimetry
• Online Access: https://www.rpmj.ru/rpmj/article/view/653
• ISSN: 2409-2231; 2410-1893

Purpose of the study. To conduct a clinical trial the efficacy of the local treatment of inflammatory processes of the skin and soft tissue combination of sodium carboxymethylcellulose with immobilized miramistin and metronidazole.Patients and methods. In patients who are hospitalized with purulent inflammation of the skin and soft tissues, which were divided into two homogeneous groups - control and experimental - to 30 patients in each. In the control group, local treatment was carried out with dioxomethyltetrahydropyrimidine ointment with chloramphenicol, and in the experimental group - a combination of miramistin and metronidazole immobilized on sodium salt of carboxymethylcellulose. The following parameters were studied in all patients in dynamics: local temperature, pH-metry of wounds, planimetric parameters, the species composition of infectious agents in the discharge from the wound was determined in dynamics, indicators of a general blood test, biochemical parameters of blood, the number of days spent in hospital.Results. On the 10th day, the percentage of reduction in the area of wounds in the experimental group was 1.6 times higher than in the control group, and the percentage of reduction in the volume of wounds was 1.5 times higher. Starting from the 5th day of treatment, local temperature indices in the experimental group were significantly lower than in the control group. Indicators of pH-metry of wounds in the experimental group, starting from the 5th day of treatment, tended to neutral values, and in the control group there was an increase in pH in the wound. During the bacteriological examination of the discharge from the wounds, it was revealed that Staphylococcus epidermidis and Staphylococcus aureus were most often sown.