Multi-component Reaction Synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles Using Ultrasonication and Dmap as Catalyst

4-(Dimethylamino)pyridine was found to be the homogenous and efficient catalyst for one-pot, multi-component reactions between hydrazine monohydrate, ethyl cyanoacetate, ketone, and malononitrile for the synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitrile derivatives using u...

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Main Authors:	Maryam Shokoohian, Nourallah Hazeri, Malek Taher Maghsoodlou, Mojtaba Lashkari
Format:	Article
Language:	English
Published:	Academy of Sciences of Moldova, Institute of Chemistry 2019-12-01
Series:	Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry
Subjects:	one-pot reaction multi-component reaction pyridine-2(1h)-one derivatives ultrasonication
Online Access:	http://www.cjm.asm.md/sites/default/files/article_files/ChemJMold_10.19261cjm.2019.639-Hazeri.pdf

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spelling	doaj-c2aecffa3159403d8356e9e8982528dd2021-07-02T12:11:33ZengAcademy of Sciences of Moldova, Institute of ChemistryChemistry Journal of Moldova: General, Industrial and Ecological Chemistry1857-17272345-16882019-12-011429710410.19261/cjm.2019.639639Multi-component Reaction Synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles Using Ultrasonication and Dmap as CatalystMaryam Shokoohian0Nourallah Hazeri1Malek Taher Maghsoodlou2Mojtaba Lashkari3 Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan 98135-674, Iran Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan 98135-674, Iran Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan 98135-674, Iran Department of Chemistry, Faculty of Science, Velayat University, Iranshahr 9911131311, Iran 4-(Dimethylamino)pyridine was found to be the homogenous and efficient catalyst for one-pot, multi-component reactions between hydrazine monohydrate, ethyl cyanoacetate, ketone, and malononitrile for the synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitrile derivatives using ultrasonication at room temperature in ethanol solution within 35-50 min with yields of over 90%. This procedure offers various remarkable features such as short reaction times, clean reaction condition, excellent yields, and easy work-up methods. http://www.cjm.asm.md/sites/default/files/article_files/ChemJMold_10.19261cjm.2019.639-Hazeri.pdf one-pot reactionmulti-component reactionpyridine-2(1h)-one derivativesultrasonication
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Maryam Shokoohian Nourallah Hazeri Malek Taher Maghsoodlou Mojtaba Lashkari
spellingShingle	Maryam Shokoohian Nourallah Hazeri Malek Taher Maghsoodlou Mojtaba Lashkari Multi-component Reaction Synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles Using Ultrasonication and Dmap as Catalyst Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry one-pot reaction multi-component reaction pyridine-2(1h)-one derivatives ultrasonication
author_facet	Maryam Shokoohian Nourallah Hazeri Malek Taher Maghsoodlou Mojtaba Lashkari
author_sort	Maryam Shokoohian
title	Multi-component Reaction Synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles Using Ultrasonication and Dmap as Catalyst
title_short	Multi-component Reaction Synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles Using Ultrasonication and Dmap as Catalyst
title_full	Multi-component Reaction Synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles Using Ultrasonication and Dmap as Catalyst
title_fullStr	Multi-component Reaction Synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles Using Ultrasonication and Dmap as Catalyst
title_full_unstemmed	Multi-component Reaction Synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles Using Ultrasonication and Dmap as Catalyst
title_sort	multi-component reaction synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles using ultrasonication and dmap as catalyst
publisher	Academy of Sciences of Moldova, Institute of Chemistry
series	Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry
issn	1857-1727 2345-1688
publishDate	2019-12-01
description	4-(Dimethylamino)pyridine was found to be the homogenous and efficient catalyst for one-pot, multi-component reactions between hydrazine monohydrate, ethyl cyanoacetate, ketone, and malononitrile for the synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitrile derivatives using ultrasonication at room temperature in ethanol solution within 35-50 min with yields of over 90%. This procedure offers various remarkable features such as short reaction times, clean reaction condition, excellent yields, and easy work-up methods.
topic	one-pot reaction multi-component reaction pyridine-2(1h)-one derivatives ultrasonication
url	http://www.cjm.asm.md/sites/default/files/article_files/ChemJMold_10.19261cjm.2019.639-Hazeri.pdf
work_keys_str_mv	AT maryamshokoohian multicomponentreactionsynthesisof16diamino2oxo1234tetrahydropyridine35dicarbonitrilesusingultrasonicationanddmapascatalyst AT nourallahhazeri multicomponentreactionsynthesisof16diamino2oxo1234tetrahydropyridine35dicarbonitrilesusingultrasonicationanddmapascatalyst AT malektahermaghsoodlou multicomponentreactionsynthesisof16diamino2oxo1234tetrahydropyridine35dicarbonitrilesusingultrasonicationanddmapascatalyst AT mojtabalashkari multicomponentreactionsynthesisof16diamino2oxo1234tetrahydropyridine35dicarbonitrilesusingultrasonicationanddmapascatalyst
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Multi-component Reaction Synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles Using Ultrasonication and Dmap as Catalyst

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