Multi-component Reaction Synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles Using Ultrasonication and Dmap as Catalyst
4-(Dimethylamino)pyridine was found to be the homogenous and efficient catalyst for one-pot, multi-component reactions between hydrazine monohydrate, ethyl cyanoacetate, ketone, and malononitrile for the synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitrile derivatives using u...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Academy of Sciences of Moldova, Institute of Chemistry
2019-12-01
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| Series: | Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry |
| Subjects: | |
| Online Access: |
http://www.cjm.asm.md/sites/default/files/article_files/ChemJMold_10.19261cjm.2019.639-Hazeri.pdf
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| Summary: | 4-(Dimethylamino)pyridine was found to be the homogenous and efficient catalyst for one-pot, multi-component reactions between hydrazine monohydrate, ethyl cyanoacetate, ketone, and malononitrile for the synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitrile derivatives using ultrasonication at room temperature in ethanol solution within 35-50 min with yields of over 90%. This procedure offers various remarkable features such as short reaction times, clean reaction condition, excellent yields, and easy work-up methods. |
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| ISSN: | 1857-1727 2345-1688 |