Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Objective. To evaluate the effectiveness and safety of coenzyme Q10 for patients with type 2 diabetes mellitus (T2DM). Methods. Data from randomized controlled trials were obtained to assess the effects of coenzyme Q10 versus placebo or western medicine on patients with T2DM. The study’s registratio...

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Main Authors: Shi-ying Zhang, Kai-lin Yang, Liu-ting Zeng, Xiao-he Wu, Hui-yong Huang
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:International Journal of Endocrinology
Online Access:http://dx.doi.org/10.1155/2018/6484839
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spelling doaj-c2ab151f743d49c2a208c0ea29b2a9422020-11-25T00:05:00ZengHindawi LimitedInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/64848396484839Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-AnalysisShi-ying Zhang0Kai-lin Yang1Liu-ting Zeng2Xiao-he Wu3Hui-yong Huang4Hunan University of Chinese Medicine, Changsha 410208, ChinaHunan University of Chinese Medicine, Changsha 410208, ChinaHunan University of Chinese Medicine, Changsha 410208, ChinaJiangxi Provincial People’s Hospital, Nanchang 330006, ChinaHunan University of Chinese Medicine, Changsha 410208, ChinaObjective. To evaluate the effectiveness and safety of coenzyme Q10 for patients with type 2 diabetes mellitus (T2DM). Methods. Data from randomized controlled trials were obtained to assess the effects of coenzyme Q10 versus placebo or western medicine on patients with T2DM. The study’s registration number is CRD42018088474. The primary outcomes included glycosylated hemoglobin, fasting blood glucose, and fasting insulin. Result. Thirteen trials involving 765 patients were included. Compared with the control group, coenzyme Q10 may decrease the HbA1c (WMD −0.29; 95% CI −0.54, −0.03; P=0.03) and the fasting blood glucose (WMD −11.21; 95% CI −18.99, −3.43; P=0.005). For fasting insulin, there is also not strong evidence that confirms which one is better because there was no statistical difference (WMD −0.48; 95% CI −2.54, 1.57; P=0.65). Conclusion. Based on current evidence, coenzyme Q10 may assist glycemic control, decrease TG, and improve HDL-C in patients with T2DM.http://dx.doi.org/10.1155/2018/6484839
collection DOAJ
language English
format Article
sources DOAJ
author Shi-ying Zhang
Kai-lin Yang
Liu-ting Zeng
Xiao-he Wu
Hui-yong Huang
spellingShingle Shi-ying Zhang
Kai-lin Yang
Liu-ting Zeng
Xiao-he Wu
Hui-yong Huang
Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
International Journal of Endocrinology
author_facet Shi-ying Zhang
Kai-lin Yang
Liu-ting Zeng
Xiao-he Wu
Hui-yong Huang
author_sort Shi-ying Zhang
title Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
title_short Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
title_full Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
title_fullStr Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
title_full_unstemmed Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
title_sort effectiveness of coenzyme q10 supplementation for type 2 diabetes mellitus: a systematic review and meta-analysis
publisher Hindawi Limited
series International Journal of Endocrinology
issn 1687-8337
1687-8345
publishDate 2018-01-01
description Objective. To evaluate the effectiveness and safety of coenzyme Q10 for patients with type 2 diabetes mellitus (T2DM). Methods. Data from randomized controlled trials were obtained to assess the effects of coenzyme Q10 versus placebo or western medicine on patients with T2DM. The study’s registration number is CRD42018088474. The primary outcomes included glycosylated hemoglobin, fasting blood glucose, and fasting insulin. Result. Thirteen trials involving 765 patients were included. Compared with the control group, coenzyme Q10 may decrease the HbA1c (WMD −0.29; 95% CI −0.54, −0.03; P=0.03) and the fasting blood glucose (WMD −11.21; 95% CI −18.99, −3.43; P=0.005). For fasting insulin, there is also not strong evidence that confirms which one is better because there was no statistical difference (WMD −0.48; 95% CI −2.54, 1.57; P=0.65). Conclusion. Based on current evidence, coenzyme Q10 may assist glycemic control, decrease TG, and improve HDL-C in patients with T2DM.
url http://dx.doi.org/10.1155/2018/6484839
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