Influence of point mutations on the stability, dimerization and oligomerization of human cystatin C and its L68Q variant

Influence of point mutations on the stability, dimerization and oligomerization of human cystatin C and its L68Q variant

Human cystatin C (hCC) is a small but very intriguing protein. Produced by all nucleated cells is found in almost all tissues and body fluids where, at physiological conditions, plays a role of a very potent inhibitor of cysteine proteases. Biologically active hCC is a monomeric protein but during c...

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Bibliographic Details
Main Authors: Aneta eSzymanska, Elżbieta eJankowska, Marta eOrlikowska, Izabela eBehrendt, Paulina eCzaplewska, Sylwia eRodziewicz-Motowidło
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Cystatin C
crystal structure
Oligomerization
stability
dimerization
mutants
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00082/full

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