Vesiculopolins, a New Class of Anti-Vesiculoviral Compounds, Inhibit Transcription Initiation of Vesiculoviruses

Vesiculopolins, a New Class of Anti-Vesiculoviral Compounds, Inhibit Transcription Initiation of Vesiculoviruses

Vesicular stomatitis virus (VSV) represents a promising platform for developing oncolytic viruses, as well as vaccines against significant human pathogens. To safely control VSV infection in humans, small-molecule drugs that selectively inhibit VSV infection may be needed. Here, using a cell-based h...

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Bibliographic Details
Main Authors: Minako Ogino, Yuriy Fedorov, Drew J. Adams, Kazuma Okada, Naoto Ito, Makoto Sugiyama, Tomoaki Ogino
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Viruses
Subjects:
vesicular stomatitis virus
Chandipura virus
vesiculoviruses
L protein
RNA-dependent RNA polymerase
transcription
small molecule inhibitor
oncolytic viruses
vaccine vectors
Online Access:https://www.mdpi.com/1999-4915/11/9/856

Internet

https://www.mdpi.com/1999-4915/11/9/856

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