Radiation Recall Reaction Induced by Adjuvant Trastuzumab (Herceptin)

• Main Authors: Caroline Chung, David Stuart, Mira Keyes
• Format: Article
• Language: English
• Published: Hindawi Limited 2009-01-01
• Series: Case Reports in Medicine
• Online Access: http://dx.doi.org/10.1155/2009/307894

Although concerns of radiation sensitization have been raised with concurrent trastuzumab (Herceptin) administration, there has been no published case of radiation recall reaction associated with trastuzumab. This case describes a clinical presentation consistent with a radiation recall reaction following administration of adjuvant trastuzumab after neoadjuvant FEC-D chemotherapy and locoregional radiotherapy for HER2-positive, locally advanced breast cancer in a premenopausal woman. Although the mechanism and etiology of radiation recall dermatitis remain unclear, this case raises further hypotheses regarding a possible drug dose-dependence and possible predisposing risk factor for the development of radiation recall reactions.