Use of Cyclic Allylic Bromides in the Zinc–Mediated Aqueous Barbier–Grignard Reaction

Use of Cyclic Allylic Bromides in the Zinc–Mediated Aqueous Barbier–Grignard Reaction

The zinc–mediated aqueous Barbier–Grignard reaction of cyclic allylic bromide substrates with various aldehydes and ketones to afford homoallylic alcohols was investigated. Aromatic aldehydes and ketones afforded adducts in good yields (66–90%) and with good diastereoselectivities. No...

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Bibliographic Details
Main Authors: Suzanne M. Perala, Brian P. Conrad, Christine A. Hughey, John H. Shugart, Gary W. Breton
Format: Article
Language:English
Published: MDPI AG 2001-07-01
Series:Molecules
Subjects:
Barbier–Grignard reaction
aqueous reactions
organozinc
homoallylic alcohols
Online Access:http://www.mdpi.com/1420-3049/6/8/655/

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