Novel Ex Vivo Culture Method for the Study of Dupuytren's Disease: Effects of TGFβ Type 1 Receptor Modulation by Antisense Oligonucleotides

Novel Ex Vivo Culture Method for the Study of Dupuytren's Disease: Effects of TGFβ Type 1 Receptor Modulation by Antisense Oligonucleotides

Dupuytren's disease (DD) is a benign fibroproliferative disease of the hand. It is characterized by the excessive production of extracellular matrix (ECM) proteins, which form a strong fibrous tissue between the handpalm and fingers, permanently disrupting the fine movement ability. The major c...

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Bibliographic Details
Main Authors: Sofia Karkampouna, Boudewijn PT Kruithof, Peter Kloen, Miryam C Obdeijn, Annelies MA van der Laan, Hans J Tanke, Dwi U Kemaladewi, Willem MH Hoogaars, Peter AC 't Hoen, Annemieke Aartsma-Rus, Ian M Clark, Peter ten Dijke, Marie-José Goumans, Marianna Kruithof-de Julio
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
Dupuytren's
exon skipping
fibrosis
TGFβ
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116302815

Internet

http://www.sciencedirect.com/science/article/pii/S2162253116302815

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