PROBING MYELIN AND AXON ABNORMALITIES SEPARATELY IN PSYCHIATRIC DISORDERS USING MRI TECHNIQUES

PROBING MYELIN AND AXON ABNORMALITIES SEPARATELY IN PSYCHIATRIC DISORDERS USING MRI TECHNIQUES

In this manuscript we present novel MRI approaches to dissecting axon vs. myelin abnormalities in psychiatric disorders. Existing DTI approaches are not able to provide specific information on these subcellular elements but novel approaches are beginning to do so. We review two approaches (magneti...

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Bibliographic Details
Main Authors: Dost eOngur, Fei eDu
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-04-01
Series:Frontiers in Integrative Neuroscience
Subjects:
myelin
Axon
MTR
DTS
g-ratio
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnint.2013.00024/full
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spelling doaj-c298fb253b264865a51e74a218201bf72020-11-24T23:50:18ZengFrontiers Media S.A.Frontiers in Integrative Neuroscience1662-51452013-04-01710.3389/fnint.2013.0002439968PROBING MYELIN AND AXON ABNORMALITIES SEPARATELY IN PSYCHIATRIC DISORDERS USING MRI TECHNIQUESDost eOngur0Fei eDu1McLean Hospital/Harvard Medical SchoolMcLean Hospital/Harvard Medical SchoolIn this manuscript we present novel MRI approaches to dissecting axon vs. myelin abnormalities in psychiatric disorders. Existing DTI approaches are not able to provide specific information on these subcellular elements but novel approaches are beginning to do so. We review two approaches (magnetization transfer ratio - MTR; and diffusion tensor spectroscopy - DTS) and the theoretical framework for interpreting data derived from these approaches. Work is ongoing to collect data that will answer some relevant questions using these techniques in schizophrenia and related conditions.http://journal.frontiersin.org/Journal/10.3389/fnint.2013.00024/fullmyelinAxonMTRDTSg-ratio
collection DOAJ
language English
format Article
sources DOAJ
author Dost eOngur
Fei eDu
spellingShingle Dost eOngur
Fei eDu
PROBING MYELIN AND AXON ABNORMALITIES SEPARATELY IN PSYCHIATRIC DISORDERS USING MRI TECHNIQUES
Frontiers in Integrative Neuroscience
myelin
Axon
MTR
DTS
g-ratio
author_facet Dost eOngur
Fei eDu
author_sort Dost eOngur
title PROBING MYELIN AND AXON ABNORMALITIES SEPARATELY IN PSYCHIATRIC DISORDERS USING MRI TECHNIQUES
title_short PROBING MYELIN AND AXON ABNORMALITIES SEPARATELY IN PSYCHIATRIC DISORDERS USING MRI TECHNIQUES
title_full PROBING MYELIN AND AXON ABNORMALITIES SEPARATELY IN PSYCHIATRIC DISORDERS USING MRI TECHNIQUES
title_fullStr PROBING MYELIN AND AXON ABNORMALITIES SEPARATELY IN PSYCHIATRIC DISORDERS USING MRI TECHNIQUES
title_full_unstemmed PROBING MYELIN AND AXON ABNORMALITIES SEPARATELY IN PSYCHIATRIC DISORDERS USING MRI TECHNIQUES
title_sort probing myelin and axon abnormalities separately in psychiatric disorders using mri techniques
publisher Frontiers Media S.A.
series Frontiers in Integrative Neuroscience
issn 1662-5145
publishDate 2013-04-01
description In this manuscript we present novel MRI approaches to dissecting axon vs. myelin abnormalities in psychiatric disorders. Existing DTI approaches are not able to provide specific information on these subcellular elements but novel approaches are beginning to do so. We review two approaches (magnetization transfer ratio - MTR; and diffusion tensor spectroscopy - DTS) and the theoretical framework for interpreting data derived from these approaches. Work is ongoing to collect data that will answer some relevant questions using these techniques in schizophrenia and related conditions.
topic myelin
Axon
MTR
DTS
g-ratio
url http://journal.frontiersin.org/Journal/10.3389/fnint.2013.00024/full
work_keys_str_mv AT dosteongur probingmyelinandaxonabnormalitiesseparatelyinpsychiatricdisordersusingmritechniques
AT feiedu probingmyelinandaxonabnormalitiesseparatelyinpsychiatricdisordersusingmritechniques
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