Synthesis of Novel Symmetrical 1,4-Disubstituted 1,2,3-Bistriazole Derivatives via ‘Click Chemistry’ and Their Biological Evaluation
A series of symmetric bis-1,2,3-triazole compounds 2–5(a–f) were synthesized as potential antioxidant agents via click chemistry. Their structures were confirmed by 1H-NMR and 13C-NMR. All of the synthesized compounds were subjected to antioxidant and antimicrobial assays. The antioxidant activity o...
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MDPI AG
2016-05-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/21/5/659 |
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doaj-c28daeadc6fe4682a46f606dc2cd0a752020-11-25T01:05:25ZengMDPI AGMolecules1420-30492016-05-0121565910.3390/molecules21050659molecules21050659Synthesis of Novel Symmetrical 1,4-Disubstituted 1,2,3-Bistriazole Derivatives via ‘Click Chemistry’ and Their Biological EvaluationEsra Düğdü0Dilek Ünlüer1Fatih Çelik2Kemal Sancak3Şengül Alpay Karaoğlu4Arzu Özel5Department of Chemistry, Karadeniz Technical University, Trabzon 61080, TurkeyDepartment of Chemistry, Karadeniz Technical University, Trabzon 61080, TurkeyDepartment of Chemistry, Karadeniz Technical University, Trabzon 61080, TurkeyDepartment of Chemistry, Karadeniz Technical University, Trabzon 61080, TurkeyDepartment of Biology, Recep Tayyip Erdoğan University, Rize 53100, TurkeyFaculty of Pharmacy, Karadeniz Technical University, Trabzon 61080, TurkeyA series of symmetric bis-1,2,3-triazole compounds 2–5(a–f) were synthesized as potential antioxidant agents via click chemistry. Their structures were confirmed by 1H-NMR and 13C-NMR. All of the synthesized compounds were subjected to antioxidant and antimicrobial assays. The antioxidant activity of these compounds (AChE inhibition, DPPH and SOD activities) was evaluated. Compound 2f was found to show the highest AChE inhibition activity of all compounds, while compound 3b showed a strong inhibitory effect on DPPH radical and compound 2a was the most effective of all compounds for SOD activity. All synthesized compounds were found to possess moderate antibacterial activity against the bacteria E. coli and Y.pseudotuberculosis.http://www.mdpi.com/1420-3049/21/5/6591,2,3-triazole1,3-dipolar cycloadditionantioxidant activityantimicrobial activity |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Esra Düğdü Dilek Ünlüer Fatih Çelik Kemal Sancak Şengül Alpay Karaoğlu Arzu Özel |
| spellingShingle |
Esra Düğdü Dilek Ünlüer Fatih Çelik Kemal Sancak Şengül Alpay Karaoğlu Arzu Özel Synthesis of Novel Symmetrical 1,4-Disubstituted 1,2,3-Bistriazole Derivatives via ‘Click Chemistry’ and Their Biological Evaluation Molecules 1,2,3-triazole 1,3-dipolar cycloaddition antioxidant activity antimicrobial activity |
| author_facet |
Esra Düğdü Dilek Ünlüer Fatih Çelik Kemal Sancak Şengül Alpay Karaoğlu Arzu Özel |
| author_sort |
Esra Düğdü |
| title |
Synthesis of Novel Symmetrical 1,4-Disubstituted 1,2,3-Bistriazole Derivatives via ‘Click Chemistry’ and Their Biological Evaluation |
| title_short |
Synthesis of Novel Symmetrical 1,4-Disubstituted 1,2,3-Bistriazole Derivatives via ‘Click Chemistry’ and Their Biological Evaluation |
| title_full |
Synthesis of Novel Symmetrical 1,4-Disubstituted 1,2,3-Bistriazole Derivatives via ‘Click Chemistry’ and Their Biological Evaluation |
| title_fullStr |
Synthesis of Novel Symmetrical 1,4-Disubstituted 1,2,3-Bistriazole Derivatives via ‘Click Chemistry’ and Their Biological Evaluation |
| title_full_unstemmed |
Synthesis of Novel Symmetrical 1,4-Disubstituted 1,2,3-Bistriazole Derivatives via ‘Click Chemistry’ and Their Biological Evaluation |
| title_sort |
synthesis of novel symmetrical 1,4-disubstituted 1,2,3-bistriazole derivatives via ‘click chemistry’ and their biological evaluation |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2016-05-01 |
| description |
A series of symmetric bis-1,2,3-triazole compounds 2–5(a–f) were synthesized as potential antioxidant agents via click chemistry. Their structures were confirmed by 1H-NMR and 13C-NMR. All of the synthesized compounds were subjected to antioxidant and antimicrobial assays. The antioxidant activity of these compounds (AChE inhibition, DPPH and SOD activities) was evaluated. Compound 2f was found to show the highest AChE inhibition activity of all compounds, while compound 3b showed a strong inhibitory effect on DPPH radical and compound 2a was the most effective of all compounds for SOD activity. All synthesized compounds were found to possess moderate antibacterial activity against the bacteria E. coli and Y.pseudotuberculosis. |
| topic |
1,2,3-triazole 1,3-dipolar cycloaddition antioxidant activity antimicrobial activity |
| url |
http://www.mdpi.com/1420-3049/21/5/659 |
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