In vitro antifungal susceptibility of Candida speciesisolated from diabetic patients

In vitro antifungal susceptibility of Candida speciesisolated from diabetic patients

Abstract INTRODUCTION This study aims to evaluate the antifungal susceptibility of different species of Candida isolated from diabetic patients against eight antifungal agents. METHODS Susceptibility testing of 111 clinical isolates of Candida species was performed against 8 antifungals using th...

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Main Authors: Mohammad Taghi Hedayati, Mahin Tavakoli, Fateme Zakavi, Tahereh Shokohi, Ramin Mofarrah, Saham Ansari, Mojtaba Taghizadeh Armaki
Format: Article
Language:English
Published: Sociedade Brasileira de Medicina Tropical (SBMT)
Series:Revista da Sociedade Brasileira de Medicina Tropical
Subjects:
Diabetes
Candida
Antifungal susceptibility test
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000400542&lng=en&tlng=en
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spelling doaj-c28ce75f3b514213a336ab54d16c1e142020-11-24T22:07:38ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-984951454254510.1590/0037-8682-0332-2017S0037-86822018000400542In vitro antifungal susceptibility of Candida speciesisolated from diabetic patientsMohammad Taghi HedayatiMahin TavakoliFateme ZakaviTahereh ShokohiRamin MofarrahSaham AnsariMojtaba Taghizadeh ArmakiAbstract INTRODUCTION This study aims to evaluate the antifungal susceptibility of different species of Candida isolated from diabetic patients against eight antifungal agents. METHODS Susceptibility testing of 111 clinical isolates of Candida species was performed against 8 antifungals using the M27-A3 protocol of the Clinical and Laboratory Standards Institute (CLSI). RESULTS Voriconazole, lanoconazole, and caspofungin showed the highest in vitro activity against all the isolates of C. albicans. Resistance against the tested antifungals was only observed in the C. albicans isolates. CONCLUSIONS Our finding revealed that resistance against amphotericin B, itraconazole, ketoconazole, posaconazole, and fluconazole can be observed in C. albicans.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000400542&lng=en&tlng=enDiabetesCandidaAntifungal susceptibility test
collection DOAJ
language English
format Article
sources DOAJ
author Mohammad Taghi Hedayati
Mahin Tavakoli
Fateme Zakavi
Tahereh Shokohi
Ramin Mofarrah
Saham Ansari
Mojtaba Taghizadeh Armaki
spellingShingle Mohammad Taghi Hedayati
Mahin Tavakoli
Fateme Zakavi
Tahereh Shokohi
Ramin Mofarrah
Saham Ansari
Mojtaba Taghizadeh Armaki
In vitro antifungal susceptibility of Candida speciesisolated from diabetic patients
Revista da Sociedade Brasileira de Medicina Tropical
Diabetes
Candida
Antifungal susceptibility test
author_facet Mohammad Taghi Hedayati
Mahin Tavakoli
Fateme Zakavi
Tahereh Shokohi
Ramin Mofarrah
Saham Ansari
Mojtaba Taghizadeh Armaki
author_sort Mohammad Taghi Hedayati
title In vitro antifungal susceptibility of Candida speciesisolated from diabetic patients
title_short In vitro antifungal susceptibility of Candida speciesisolated from diabetic patients
title_full In vitro antifungal susceptibility of Candida speciesisolated from diabetic patients
title_fullStr In vitro antifungal susceptibility of Candida speciesisolated from diabetic patients
title_full_unstemmed In vitro antifungal susceptibility of Candida speciesisolated from diabetic patients
title_sort in vitro antifungal susceptibility of candida speciesisolated from diabetic patients
publisher Sociedade Brasileira de Medicina Tropical (SBMT)
series Revista da Sociedade Brasileira de Medicina Tropical
issn 1678-9849
description Abstract INTRODUCTION This study aims to evaluate the antifungal susceptibility of different species of Candida isolated from diabetic patients against eight antifungal agents. METHODS Susceptibility testing of 111 clinical isolates of Candida species was performed against 8 antifungals using the M27-A3 protocol of the Clinical and Laboratory Standards Institute (CLSI). RESULTS Voriconazole, lanoconazole, and caspofungin showed the highest in vitro activity against all the isolates of C. albicans. Resistance against the tested antifungals was only observed in the C. albicans isolates. CONCLUSIONS Our finding revealed that resistance against amphotericin B, itraconazole, ketoconazole, posaconazole, and fluconazole can be observed in C. albicans.
topic Diabetes
Candida
Antifungal susceptibility test
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000400542&lng=en&tlng=en
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