Iron Metabolism Dysregulation and Cognitive Dysfunction in Pediatric Obesity: Is There a Connection?

Obesity and iron deficiency (ID) are two of the most common nutritional disorders in the world. In children both conditions deserve particular attention. Several studies revealed an association between obesity and iron deficiency in children and, in some cases, a reduced response to oral supplementa...

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Main Authors:	Anna Grandone, Pierluigi Marzuillo, Laura Perrone, Emanuele Miraglia del Giudice
Format:	Article
Language:	English
Published:	MDPI AG 2015-11-01
Series:	Nutrients
Subjects:	obesity iron deficiency cognitive dysfunction hepcidin children
Online Access:	http://www.mdpi.com/2072-6643/7/11/5458

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spelling	doaj-c275c3261b92417082ea01b60297d10e2020-11-24T22:21:23ZengMDPI AGNutrients2072-66432015-11-017119163917010.3390/nu7115458nu7115458Iron Metabolism Dysregulation and Cognitive Dysfunction in Pediatric Obesity: Is There a Connection?Anna Grandone0Pierluigi Marzuillo1Laura Perrone2Emanuele Miraglia del Giudice3Department of Woman, Child, General and Specialized Surgery, Second University of Naples Via De Crecchio 2–4, Naples 80138, ItalyDepartment of Woman, Child, General and Specialized Surgery, Second University of Naples Via De Crecchio 2–4, Naples 80138, ItalyDepartment of Woman, Child, General and Specialized Surgery, Second University of Naples Via De Crecchio 2–4, Naples 80138, ItalyDepartment of Woman, Child, General and Specialized Surgery, Second University of Naples Via De Crecchio 2–4, Naples 80138, ItalyObesity and iron deficiency (ID) are two of the most common nutritional disorders in the world. In children both conditions deserve particular attention. Several studies revealed an association between obesity and iron deficiency in children and, in some cases, a reduced response to oral supplementation. The connecting mechanism, however, is not completely known. This review is focused on: (1) iron deficiency in obese children and the role of hepcidin in the connection between body fat and poor iron status; (2) iron status and consequences on health, in particular on cognitive function; (3) cognitive function and obesity; (4) suggestion of a possible link between cognitive dysfunction and ID in pediatric obesity; and implications for therapy and future research.http://www.mdpi.com/2072-6643/7/11/5458obesityiron deficiencycognitive dysfunctionhepcidinchildren
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Anna Grandone Pierluigi Marzuillo Laura Perrone Emanuele Miraglia del Giudice
spellingShingle	Anna Grandone Pierluigi Marzuillo Laura Perrone Emanuele Miraglia del Giudice Iron Metabolism Dysregulation and Cognitive Dysfunction in Pediatric Obesity: Is There a Connection? Nutrients obesity iron deficiency cognitive dysfunction hepcidin children
author_facet	Anna Grandone Pierluigi Marzuillo Laura Perrone Emanuele Miraglia del Giudice
author_sort	Anna Grandone
title	Iron Metabolism Dysregulation and Cognitive Dysfunction in Pediatric Obesity: Is There a Connection?
title_short	Iron Metabolism Dysregulation and Cognitive Dysfunction in Pediatric Obesity: Is There a Connection?
title_full	Iron Metabolism Dysregulation and Cognitive Dysfunction in Pediatric Obesity: Is There a Connection?
title_fullStr	Iron Metabolism Dysregulation and Cognitive Dysfunction in Pediatric Obesity: Is There a Connection?
title_full_unstemmed	Iron Metabolism Dysregulation and Cognitive Dysfunction in Pediatric Obesity: Is There a Connection?
title_sort	iron metabolism dysregulation and cognitive dysfunction in pediatric obesity: is there a connection?
publisher	MDPI AG
series	Nutrients
issn	2072-6643
publishDate	2015-11-01
description	Obesity and iron deficiency (ID) are two of the most common nutritional disorders in the world. In children both conditions deserve particular attention. Several studies revealed an association between obesity and iron deficiency in children and, in some cases, a reduced response to oral supplementation. The connecting mechanism, however, is not completely known. This review is focused on: (1) iron deficiency in obese children and the role of hepcidin in the connection between body fat and poor iron status; (2) iron status and consequences on health, in particular on cognitive function; (3) cognitive function and obesity; (4) suggestion of a possible link between cognitive dysfunction and ID in pediatric obesity; and implications for therapy and future research.
topic	obesity iron deficiency cognitive dysfunction hepcidin children
url	http://www.mdpi.com/2072-6643/7/11/5458
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Iron Metabolism Dysregulation and Cognitive Dysfunction in Pediatric Obesity: Is There a Connection?

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