SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose.

SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose.

Although excessive fructose intake is epidemiologically linked with dyslipidemia, obesity, and diabetes, the mechanisms regulating plasma fructose are not well known. Cells transfected with sodium/glucose cotransporter 5 (SGLT5), which is expressed exclusively in the kidney, transport fructose in vi...

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Main Authors: Taku Fukuzawa, Masanori Fukazawa, Otoya Ueda, Hideaki Shimada, Aki Kito, Mami Kakefuda, Yosuke Kawase, Naoko A Wada, Chisato Goto, Naoshi Fukushima, Kou-Ichi Jishage, Kiyofumi Honda, George L King, Yoshiki Kawabe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3581502?pdf=render

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