Delirium and seizures in a patient with head-and-neck squamous cell carcinoma on docetaxel, cisplatin, and 5-fluorouracil

Delirium and seizures in a patient with head-and-neck squamous cell carcinoma on docetaxel, cisplatin, and 5-fluorouracil

A 33 year male, case of locally advanced carcinoma left buccal mucosa treated with docetaxel, cisplatin and 5-fluorouracil as neoadjuvant therapy developed acute onset delirium, seizures and agitation on fifth day of first cycle of chemotherapy. Although CT brain revealed no abnormality, MRI brain s...

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Bibliographic Details
Main Authors: Satvik Khaddar, Vijay M Patil, Vanita Noronha, Amit Joshi, Nandini Menon, Kumar Prabhash
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Cancer Research, Statistics, and Treatment
Subjects:
5-fluorouracil
delirium
diffusion restriction
leukoencephalopathy
t2/flair hyperintensity
Online Access:http://www.crstonline.com/article.asp?issn=2590-3233;year=2019;volume=2;issue=1;spage=105;epage=107;aulast=
Description
Summary:A 33 year male, case of locally advanced carcinoma left buccal mucosa treated with docetaxel, cisplatin and 5-fluorouracil as neoadjuvant therapy developed acute onset delirium, seizures and agitation on fifth day of first cycle of chemotherapy. Although CT brain revealed no abnormality, MRI brain showed symmetric areas of diffusion restriction with T2/FLAIR hyperintensity involving periventricular region (lateral ventricles), centrum semiovale and corpus callosum. His clinical symptoms normalized after one week of stopping therapy. What is the diagnosis, and how should the patient be managed?
ISSN:2590-3233
2590-3225

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