An in vitro iron superoxide dismutase inhibitor decreases the parasitemia levels of Trypanosoma cruzi in BALB/c mouse model during acute phase

In order to identify new compounds to treat Chagas disease during the acute phase with higher activity and lower toxicity than the reference drug benznidazole (Bz), two hydroxyphthalazine derivative compounds were prepared and their trypanocidal effects against Trypanosoma cruzi were evaluated by li...

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Bibliographic Details
Main Authors: Francisco Olmo, Kristína Urbanová, Maria Jose Rosales, Ruben Martín-Escolano, Manuel Sánchez-Moreno, Clotilde Marín
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S221132071500010X