Novel Group of AChE Reactivators—Synthesis, In Vitro Reactivation and Molecular Docking Study

Novel Group of AChE Reactivators—Synthesis, In Vitro Reactivation and Molecular Docking Study

The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam. They are referred to as a causal treatment of OP poisoning, because they are able to split the OP moiety from AChE activ...

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Bibliographic Details
Main Authors: David Malinak, Eugenie Nepovimova, Daniel Jun, Kamil Musilek, Kamil Kuca
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Molecules
Subjects:
organophosphate
acetylcholinesterase
reactivation
oxime
in vitro
molecular docking
Online Access:http://www.mdpi.com/1420-3049/23/9/2291

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