Looking Back, Looking Forward at Halogen Bonding in Drug Discovery
Halogen bonding has emerged at the forefront of advances in improving ligand: receptor interactions. In particular the newfound ability of this extant non-covalent-bonding phenomena has revolutionized computational approaches to drug discovery while simultaneously reenergizing synthetic approaches t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/22/9/1397 |
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doaj-c262db86f0514a179997e44ae36000372020-11-24T21:45:45ZengMDPI AGMolecules1420-30492017-08-01229139710.3390/molecules22091397molecules22091397Looking Back, Looking Forward at Halogen Bonding in Drug DiscoveryLois Mendez0Gabriela Henriquez1Suman Sirimulla2Mahesh Narayan3Department of Chemistry, The University of Texas at El Paso, El Paso, TX 79968, USAEnvironmental Science and Engineering Program, The University of Texas at El Paso, El Paso, TX 79968, USASchool of Pharmacy, The University of Texas at El Paso, El Paso, TX 79968, USADepartment of Chemistry, The University of Texas at El Paso, El Paso, TX 79968, USAHalogen bonding has emerged at the forefront of advances in improving ligand: receptor interactions. In particular the newfound ability of this extant non-covalent-bonding phenomena has revolutionized computational approaches to drug discovery while simultaneously reenergizing synthetic approaches to the field. Here we survey, via examples of classical applications involving halogen atoms in pharmaceutical compounds and their biological hosts, the unique advantages that halogen atoms offer as both Lewis acids and Lewis bases.https://www.mdpi.com/1420-3049/22/9/1397halogen bondingsigma-holeLewis baseLewis aciddrug discovery |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Lois Mendez Gabriela Henriquez Suman Sirimulla Mahesh Narayan |
| spellingShingle |
Lois Mendez Gabriela Henriquez Suman Sirimulla Mahesh Narayan Looking Back, Looking Forward at Halogen Bonding in Drug Discovery Molecules halogen bonding sigma-hole Lewis base Lewis acid drug discovery |
| author_facet |
Lois Mendez Gabriela Henriquez Suman Sirimulla Mahesh Narayan |
| author_sort |
Lois Mendez |
| title |
Looking Back, Looking Forward at Halogen Bonding in Drug Discovery |
| title_short |
Looking Back, Looking Forward at Halogen Bonding in Drug Discovery |
| title_full |
Looking Back, Looking Forward at Halogen Bonding in Drug Discovery |
| title_fullStr |
Looking Back, Looking Forward at Halogen Bonding in Drug Discovery |
| title_full_unstemmed |
Looking Back, Looking Forward at Halogen Bonding in Drug Discovery |
| title_sort |
looking back, looking forward at halogen bonding in drug discovery |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2017-08-01 |
| description |
Halogen bonding has emerged at the forefront of advances in improving ligand: receptor interactions. In particular the newfound ability of this extant non-covalent-bonding phenomena has revolutionized computational approaches to drug discovery while simultaneously reenergizing synthetic approaches to the field. Here we survey, via examples of classical applications involving halogen atoms in pharmaceutical compounds and their biological hosts, the unique advantages that halogen atoms offer as both Lewis acids and Lewis bases. |
| topic |
halogen bonding sigma-hole Lewis base Lewis acid drug discovery |
| url |
https://www.mdpi.com/1420-3049/22/9/1397 |
| work_keys_str_mv |
AT loismendez lookingbacklookingforwardathalogenbondingindrugdiscovery AT gabrielahenriquez lookingbacklookingforwardathalogenbondingindrugdiscovery AT sumansirimulla lookingbacklookingforwardathalogenbondingindrugdiscovery AT maheshnarayan lookingbacklookingforwardathalogenbondingindrugdiscovery |
| _version_ |
1725904413004922880 |