Lysophosphatidic Acid–Induced EGFR Transactivation Promotes Gastric Cancer Cell DNA Replication by Stabilizing Geminin in the S Phase

Lysophosphatidic Acid–Induced EGFR Transactivation Promotes Gastric Cancer Cell DNA Replication by Stabilizing Geminin in the S Phase

Geminin, an inhibitor of the DNA replication licensing factor, chromatin licensing and DNA replication factor (Cdt) 1, is essential for the maintenance of genomic integrity. As a multifunctional protein, geminin is also involved in tumor progression, but the molecular details are largely unknown. He...

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Bibliographic Details
Main Authors: Haile Zhao, Gezi Gezi, Xiaoxia Tian, Peijun Jia, Morigen Morigen, Lifei Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
LPA
EGFR
transactivation
DNA replication
geminin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.706240/full

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