Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi

Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi

Glucose-6-phosphate dehydrogenase (G6PDH) plays a housekeeping role in cell metabolism by generating reducing power (NADPH) and fueling the production of nucleotide precursors (ribose-5-phosphate). Based on its indispensability for pathogenic parasites from the genus Trypanosoma, G6PDH is considered...

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Bibliographic Details
Main Authors: Cecilia Ortiz, Francesca Moraca, Andrea Medeiros, Maurizio Botta, Niall Hamilton, Marcelo A. Comini
Format: Article
Language:English
Published: MDPI AG 2016-03-01
Series:Molecules
Subjects:
epiandrosterone
pentose phosphate pathway
Chagas disease
Leishmania
inhibition by steroids
structure activity relationship
Online Access:http://www.mdpi.com/1420-3049/21/3/368

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