Development of Chemical Tools to Monitor Human Kallikrein 13 (KLK13) Activity

Development of Chemical Tools to Monitor Human Kallikrein 13 (KLK13) Activity

Kallikrein 13 (KLK13) was first identified as an enzyme that is downregulated in a subset of breast tumors. This serine protease has since been implicated in a number of pathological processes including ovarian, lung and gastric cancers. Here we report the design, synthesis and deconvolution of libr...

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Bibliographic Details
Main Authors: Natalia Gruba, Ewa Bielecka, Magdalena Wysocka, Anna Wojtysiak, Magdalena Brzezińska-Bodal, Kamila Sychowska, Magdalena Kalińska, Małgorzata Magoch, Aleksandra Pęcak, Katherine Falkowski, Magdalena Wiśniewska, Laura Sąsiadek, Karolina Płaza, Eileen Kroll, Anastasija Pejkovska, Maren Rehders, Klaudia Brix, Grzegorz Dubin, Tomasz Kantyka, Jan Potempa, Adam Lesner
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
KLK13
substrate specificity
combinatorial chemistry
fluorogenic substrate
activity-based probe
Online Access:https://www.mdpi.com/1422-0067/20/7/1557

Internet

https://www.mdpi.com/1422-0067/20/7/1557

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