Endometrial Serous Carcinoma Arising from Adenomyosis: A Clinico-Pathological Insight

• Main Authors: Amrita Talwar, Pushpanjali Behera, Arvind Ahuja, Bani Sarkar, Ravi Hari Phulware
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2021-06-01
• Series: Journal of Family and Reproductive Health
• Subjects: Endometrial Neoplasms; Adenomyosis; Menopause; Carcinoma in Situ; Endometrium; Carcinoma
• Online Access: https://jfrh.tums.ac.ir/index.php/jfrh/article/view/1622

Objective: Endometrial cancer (EC) is the most commonly diagnosed malignancy and has the second-highest mortality rate among gynecological cancers. Adenomyosis is well-known for abnormal uterine bleeding and is a widely reported entity; however, an EC arising from the adenomyosis is a rare event; even rarer is the occurrence of serous endometrial carcinoma. Case report: A 60-year post-menopausal female presented with post-menopausal bleeding. Subsequently, she underwent a hysterectomy, which showed atrophic and cystic endometrium with extensive adenomyosis and atypical endometrial glands, which are diffusely P53 positive with intervening negative benign and focally positive dysplastic endometrial glands. A final diagnosis of serous endometrial carcinoma arising from adenomyosis was rendered. In a table format, previously reported serous endometrial carcinoma Arising cases from adenomyosis using PubMed search had been described. Conclusion: Serous endometrial carcinoma arising from adenomyosis (<20 cases reported) and has a slightly more dismal prognosis than those deriving from the endometrial cavity. Hence, this case report highlights the occurrence, rarity, and importance of such an entity.