Overexpression of Smad7 in hypothalamic POMC neurons disrupts glucose balance by attenuating central insulin signaling

Overexpression of Smad7 in hypothalamic POMC neurons disrupts glucose balance by attenuating central insulin signaling

Objective: Although the hypothalamus is crucial for peripheral metabolism control, the signals in specific neurons involved remain poorly understood. The aim of our current study was to explore the role of the hypothalamic gene mothers against decapentaplegic homolog 7 (Smad7) in peripheral glucose...

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Bibliographic Details
Main Authors: Feixiang Yuan, Hanrui Yin, Yalan Deng, Fuxin Jiao, Haizhou Jiang, Yuguo Niu, Shanghai Chen, Hao Ying, Qiwei Zhai, Yan Chen, Feifan Guo
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Metabolism
Subjects:
Glucose disorders
Insulin signaling
POMC neurons
Smad7
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820301587

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