Trypsinogen activation peptide induces HMGB1 release from rat pancreatic acinar cells

Trypsinogen activation peptide induces HMGB1 release from rat pancreatic acinar cells

The development of acute pancreatitis (AP) is associated with intracellular events in pancreatic cells, as well as with early and late inflammatory responses; however, their underlying mechanisms remain unclear. This study investigated trypsinogen activation peptide (TAP)-induced release of high mob...

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Bibliographic Details
Main Authors: Wang Guoliang, Liu Yan, Dui Danhua, Bai Liang, Liu Yao, Tian Fei, Wei Wei
Format: Article
Language:English
Published: De Gruyter 2017-09-01
Series:Open Medicine
Subjects:
Pancreatic acinar cell
Trypsinogen activation peptide
High mobility group box-1
Ethyl pyruvate
Rat
Online Access:http://www.degruyter.com/view/j/med.2017.12.issue-1/med-2017-0043/med-2017-0043.xml?format=INT
Description
Summary:The development of acute pancreatitis (AP) is associated with intracellular events in pancreatic cells, as well as with early and late inflammatory responses; however, their underlying mechanisms remain unclear. This study investigated trypsinogen activation peptide (TAP)-induced release of high mobility group box-l (HMGB1) from pancreatic acinar cells and how ethyl pyruvate (EP) affects this release.
ISSN:2391-5463

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