Clinical manifestations of anemia syndrome and its significance in the course of chronic heart failure in elderly patients

• Main Authors: V N Larina, B Ia Bart
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2014-03-01
• Series: Терапевтический архив
• Subjects: chronic heart failure; elderly patients; anemia; prognosis; hospitalization
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/31458
• ISSN: 0040-3660; 2309-5342

AIM: To define the practical significance of anemia in the course of chronic heart failure (CHF) in elderly outpatients/MATERIAL AND METHODS: One hundred and sixty-four patients aged 60 to 85 years with NYHA classification Functional Class (FC) II-IV CHF due to coronary heart disease and arterial hypertension were examined. Clinical, laboratory, and echocardiographic parameters were assessed; admissions and fatal outcomes were recorded. The follow-up was 2.5±2.1 years/RESULTS: Anemia syndrome was recorded in 32.9% of the patients (women were 43.5% and men were 26.5%) (p=0.024). There was an association between decreased hemoglobin levels and renal dysfunction (odds ratio (OR) 2.04; 95% confidence interval, 1.05 to 3.98; p=0.036). In all the patients, anemia was mild and similar in its pattern and etiology, regardless of gender. Because of decompensated CHF, 46.3% of the patients with anemia and 22.7% of those without this condition were admitted to hospital (p=0.002). The survival rates of the elderly CHF patients with and without anemia were equal (p=0.549); however, comparison of only the patients with anemia showed a difference in male and female survival rates (p=0.005). FC III-IV CHF (OR 4.37), chronic kidney disease (OR 2.27%), and a left ventricular ejection fraction of