Specific dynamic action of food in patients with chronic pancreatitis accompanied with metabolic syndrome

• Main Authors: Yakov Maksimovich Vakhrushev, Anna Aleksandrovna Volkova, Ya M Vakhrushev, A A Volkova
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2012-02-01
• Series: Терапевтический архив
• Subjects: chronic pancreatitis; metabolic syndrome; specific dynamic action of food; insulin resistance
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/30998
• ISSN: 0040-3660; 2309-5342

Aim. To study hormone component of food specific dynamic action (FSDA) in chronic pancreatitis (CP) accompanied with metabolic syndrome (MS). Material and methods. A total of 60 patients were examined: 30 patients with CP and 30 patients with CP accompanied with MS. The study of fasting levels of thyrotrophic hormone, thyroxin, cortisol, insulin, C-peptide was conducted as well as one and two hours after carbohydrate breakfast to assess development of FSDA. Results. The study revealed that development of FSDA is characterized by systemic reaction, including changes in multiple hormonal parameters. However, patients with CP accompanied with MS demonstrated abnormal basal secretion and postprandial secretory responses of the above hormones. The absence of hormonal responses to food intake impairs FSDA and thus is involved in pathogenesis of metabolic disorders in patients with CP accompanied with MS. Conclusion. The study of the development of FSDA brings valuable information that can be used in clinical practice for studying mechanisms of metabolic disorders in various pathological conditions.