Synthesis and Evaluation of 3-Substituted-4-(quinoxalin-6-yl) Pyrazoles as TGF-β Type I Receptor Kinase Inhibitors

Synthesis and Evaluation of 3-Substituted-4-(quinoxalin-6-yl) Pyrazoles as TGF-β Type I Receptor Kinase Inhibitors

The transforming growth factor-&#946; (TGF-&#946;), in which overexpression has been associated with various diseases, has become an attractive molecular target for the treatment of cancers. Thirty-two quinoxaline-derivatives of 3-substituted-4-(quinoxalin-6-yl) pyrazoles <b>14a</b&...

Full description

Bibliographic Details
Main Authors: Li-Min Zhao, Zhen Guo, Yi-Jie Xue, Jun Zhe Min, Wen-Jing Zhu, Xiang-Yu Li, Hu-Ri Piao, Cheng Hua Jin
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Molecules
Subjects:
TGF-β
ALK5 inhibitor
kinase assay
selectivity
docking
Online Access:https://www.mdpi.com/1420-3049/23/12/3369

Internet

https://www.mdpi.com/1420-3049/23/12/3369

Similar Items