| Summary: | Introduction. The management of pregnancy in young women with essential
thrombocythemia is complex and may present a difficult problem. An adverse
pregnancy outcome due to thrombosis or bleeding is a common complication. In
addition, little is known about fertility in these women prior to the
disease. Case Outline. We present the first case of a young woman with
primary infertility and essential thrombocythemia who had uneventfully
delivered a healthy boy in the fortieth week of pregnancy. Her platelet count
was normalized during treatment with interferon-alfa.The patient failed to
become pregnant in the natural way and after three attempts of programmed
intercourse. She conceived only following intrauterine insemination. During
pregnancy, the patient was carefully controlled by a hematologist and
gynecologist. Conclusion. Natural course and prognosis of essential
thrombocythemia is not adversely affected by pregnancy. In these women, the
pregnancy should be planned only after normalization of platelet count. The
interferon-alpha should be administered before the pregnancy to regulate and
maintain the platelet count within the normal range. Intrauterine
insemination with minimal hormonal stimulation due to the risk of thrombosis
could be recommended as the safest treatment option of infertility in women
with essential thrombocythemia.
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