Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway

Molecular mechanisms regulating optimal myelin geometry are only partially understood. Here authors show that peripheral myelin growth is orchestrated by the Crb3/Hippo/YAP pathway, and that defects in YAP activation may underlie peripheral neuropathies caused by shorter myelin.

Bibliographic Details
Main Authors:	Ruani N. Fernando, Laurent Cotter, Claire Perrin-Tricaud, Jade Berthelot, Sylvain Bartolami, Jorge A. Pereira, Sergio Gonzalez, Ueli Suter, Nicolas Tricaud
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms12186

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spelling	doaj-c1f6ad2ca61c49ab91342b2741d1490a2021-05-11T10:47:31ZengNature Publishing GroupNature Communications2041-17232016-07-017111410.1038/ncomms12186Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathwayRuani N. Fernando0Laurent Cotter1Claire Perrin-Tricaud2Jade Berthelot3Sylvain Bartolami4Jorge A. Pereira5Sergio Gonzalez6Ueli Suter7Nicolas Tricaud8Institut des Neurosciences de Montpellier, INSERM U1051, University of Montpellier, Hopital Saint EloiInstitut des Neurosciences de Montpellier, INSERM U1051, University of Montpellier, Hopital Saint EloiInstitut des Neurosciences de Montpellier, INSERM U1051, University of Montpellier, Hopital Saint EloiInstitut des Neurosciences de Montpellier, INSERM U1051, University of Montpellier, Hopital Saint EloiInstitut des Neurosciences de Montpellier, INSERM U1051, University of Montpellier, Hopital Saint EloiETH, Institute of Molecular Health SciencesInstitut des Neurosciences de Montpellier, INSERM U1051, University of Montpellier, Hopital Saint EloiETH, Institute of Molecular Health SciencesInstitut des Neurosciences de Montpellier, INSERM U1051, University of Montpellier, Hopital Saint EloiMolecular mechanisms regulating optimal myelin geometry are only partially understood. Here authors show that peripheral myelin growth is orchestrated by the Crb3/Hippo/YAP pathway, and that defects in YAP activation may underlie peripheral neuropathies caused by shorter myelin.https://doi.org/10.1038/ncomms12186
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ruani N. Fernando Laurent Cotter Claire Perrin-Tricaud Jade Berthelot Sylvain Bartolami Jorge A. Pereira Sergio Gonzalez Ueli Suter Nicolas Tricaud
spellingShingle	Ruani N. Fernando Laurent Cotter Claire Perrin-Tricaud Jade Berthelot Sylvain Bartolami Jorge A. Pereira Sergio Gonzalez Ueli Suter Nicolas Tricaud Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway Nature Communications
author_facet	Ruani N. Fernando Laurent Cotter Claire Perrin-Tricaud Jade Berthelot Sylvain Bartolami Jorge A. Pereira Sergio Gonzalez Ueli Suter Nicolas Tricaud
author_sort	Ruani N. Fernando
title	Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway
title_short	Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway
title_full	Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway
title_fullStr	Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway
title_full_unstemmed	Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway
title_sort	optimal myelin elongation relies on yap activation by axonal growth and inhibition by crb3/hippo pathway
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-07-01
description	Molecular mechanisms regulating optimal myelin geometry are only partially understood. Here authors show that peripheral myelin growth is orchestrated by the Crb3/Hippo/YAP pathway, and that defects in YAP activation may underlie peripheral neuropathies caused by shorter myelin.
url	https://doi.org/10.1038/ncomms12186
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Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway

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