Lysosomal pH-inducible supramolecular dissociation of polyrotaxanes possessing acid-labile N-triphenylmethyl end groups and their therapeutic potential for Niemann-Pick type C disease

Lysosomal pH-inducible supramolecular dissociation of polyrotaxanes possessing acid-labile N-triphenylmethyl end groups and their therapeutic potential for Niemann-Pick type C disease

Niemann-Pick type C (NPC) disease is characterized by the accumulation of cholesterol in lysosomes. We have previously reported that biocleavable polyrotaxanes (PRXs) composed of β-cyclodextrins (β-CDs) threaded onto a linear polymer capped with bulky stopper molecules via intracellularly cleavable...

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Bibliographic Details
Main Authors: Atsushi Tamura, Kei Nishida, Nobuhiko Yui
Format: Article
Language:English
Published: Taylor & Francis Group 2016-01-01
Series:Science and Technology of Advanced Materials
Subjects:
polyrotaxane
cyclodextrin
triphenylmethyl group
cholesterol
niemann-pick type c disease
Online Access:http://dx.doi.org/10.1080/14686996.2016.1200948

Internet

http://dx.doi.org/10.1080/14686996.2016.1200948

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