Acute drug transfer and particle release of drug coated balloons within a porcine in-vitro model
Drug coated balloons (DCB) are used in the therapy of coronary as well as peripheral artery disease. The success of drug transfer to the vessel wall depends on the excipient used in combination with paclitaxel as antiproliferative drug. Although in-vivo studies show very good results with this techn...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2017-09-01
|
| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2017-0098 |
| id |
doaj-c1dfd249bf4e4ddb8c1f40317e427f23 |
|---|---|
| record_format |
Article |
| spelling |
doaj-c1dfd249bf4e4ddb8c1f40317e427f232021-09-06T19:19:25ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042017-09-013246546810.1515/cdbme-2017-0098cdbme-2017-0098Acute drug transfer and particle release of drug coated balloons within a porcine in-vitro modelBrandt-Wunderlich Christoph0Almstädt Lucas1Kaule Sebastian2Reske Thomas3Schmidt Wolfram4Schmitz Klaus-Peter5Grabow Niels6Institute for ImplantTechnology and Biomaterials e.V., Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemuende, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemuende, GermanyInstitute for ImplantTechnology and Biomaterials e.V., Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemuende, GermanyInstitute for ImplantTechnology and Biomaterials e.V., Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemuende, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemuende, GermanyInstitute for ImplantTechnology and Biomaterials e.V. and Institute for Biomedical Engineering, Rostock University Medical Center, Rostock-Warnemuende, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemuende, GermanyDrug coated balloons (DCB) are used in the therapy of coronary as well as peripheral artery disease. The success of drug transfer to the vessel wall depends on the excipient used in combination with paclitaxel as antiproliferative drug. Although in-vivo studies show very good results with this technology, there is a lack of in-vitro test methods for characterization of various DCB available on the market. This study describes a method to gain information about the drug transfer and the particle release of three different DCB based on cetylpyridinium salycate (Cetpyrsal), hyaluronic acid and iopromide within a porcine in-vitro model. The Cetpyrsal-based DCB showed promising results with the highest drug transfer while producing the lowest number of particles.https://doi.org/10.1515/cdbme-2017-0098drug coated balloondrug transferin-vitropaclitaxelparticulate evaluation |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Brandt-Wunderlich Christoph Almstädt Lucas Kaule Sebastian Reske Thomas Schmidt Wolfram Schmitz Klaus-Peter Grabow Niels |
| spellingShingle |
Brandt-Wunderlich Christoph Almstädt Lucas Kaule Sebastian Reske Thomas Schmidt Wolfram Schmitz Klaus-Peter Grabow Niels Acute drug transfer and particle release of drug coated balloons within a porcine in-vitro model Current Directions in Biomedical Engineering drug coated balloon drug transfer in-vitro paclitaxel particulate evaluation |
| author_facet |
Brandt-Wunderlich Christoph Almstädt Lucas Kaule Sebastian Reske Thomas Schmidt Wolfram Schmitz Klaus-Peter Grabow Niels |
| author_sort |
Brandt-Wunderlich Christoph |
| title |
Acute drug transfer and particle release of drug coated balloons within a porcine in-vitro model |
| title_short |
Acute drug transfer and particle release of drug coated balloons within a porcine in-vitro model |
| title_full |
Acute drug transfer and particle release of drug coated balloons within a porcine in-vitro model |
| title_fullStr |
Acute drug transfer and particle release of drug coated balloons within a porcine in-vitro model |
| title_full_unstemmed |
Acute drug transfer and particle release of drug coated balloons within a porcine in-vitro model |
| title_sort |
acute drug transfer and particle release of drug coated balloons within a porcine in-vitro model |
| publisher |
De Gruyter |
| series |
Current Directions in Biomedical Engineering |
| issn |
2364-5504 |
| publishDate |
2017-09-01 |
| description |
Drug coated balloons (DCB) are used in the therapy of coronary as well as peripheral artery disease. The success of drug transfer to the vessel wall depends on the excipient used in combination with paclitaxel as antiproliferative drug. Although in-vivo studies show very good results with this technology, there is a lack of in-vitro test methods for characterization of various DCB available on the market. This study describes a method to gain information about the drug transfer and the particle release of three different DCB based on cetylpyridinium salycate (Cetpyrsal), hyaluronic acid and iopromide within a porcine in-vitro model. The Cetpyrsal-based DCB showed promising results with the highest drug transfer while producing the lowest number of particles. |
| topic |
drug coated balloon drug transfer in-vitro paclitaxel particulate evaluation |
| url |
https://doi.org/10.1515/cdbme-2017-0098 |
| work_keys_str_mv |
AT brandtwunderlichchristoph acutedrugtransferandparticlereleaseofdrugcoatedballoonswithinaporcineinvitromodel AT almstadtlucas acutedrugtransferandparticlereleaseofdrugcoatedballoonswithinaporcineinvitromodel AT kaulesebastian acutedrugtransferandparticlereleaseofdrugcoatedballoonswithinaporcineinvitromodel AT reskethomas acutedrugtransferandparticlereleaseofdrugcoatedballoonswithinaporcineinvitromodel AT schmidtwolfram acutedrugtransferandparticlereleaseofdrugcoatedballoonswithinaporcineinvitromodel AT schmitzklauspeter acutedrugtransferandparticlereleaseofdrugcoatedballoonswithinaporcineinvitromodel AT grabowniels acutedrugtransferandparticlereleaseofdrugcoatedballoonswithinaporcineinvitromodel |
| _version_ |
1717778642420891648 |