PATTERNS OF LOCAL AND GENERAL IMMUNITY AMONG CHILDREN SUFFERING FROM COMMON ILLNESSES ACCOMPLISHED BY LYMPHADENOPATHIES

• Main Authors: N. N. Popov, A. N. Savvo, E. A. Romanova
• Format: Article
• Language: Russian
• Published: SPb RAACI 2014-07-01
• Series: Medicinskaâ Immunologiâ
• Subjects: т-lymphocytes; в-lymphocytes; lymphocyte subpopulations; immunity; lymphadenopathies; children
• Online Access: https://www.mimmun.ru/mimmun/article/view/374

Abstract. We have studied some features of immune system in children with common episodes of acute respiratory infections accompanied by lymphadenopathies (LAP). Among this cohort of the patients, a decrease in general immune reactions was revealed, accomplished by polyclonal activation of distinct lymphocyte subpopulations. Certain immune changes have been discerned in children with common infections accompanied by a LAP syndrome, such as an increased ratios of T- and B-lymphocytes carrying CD69 and CD25 activation molecules, a CD71 marker typical for proliferating cells, NKT-cells positive for CD3, CD56, CD8 with high cytokine-producing potential, as well as increased rates of spontaneous blast transformation of lymphocytes, both in course of the disease, and following recovery of the children.