Impact of body size, nutrition and socioeconomic position in early life on the epigenome: a systematic review protocol
Abstract Background Body size, nutrition and socioeconomic position (SEP) in early life have been associated with a range of later life health outcomes. Epigenetic regulation is one mechanism through which these early life factors may impact later life health. The aim of this review protocol is to o...
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doaj-c1cd758046504e2ebaa34655e4cc86012020-11-25T00:21:26ZengBMCSystematic Reviews2046-40532017-07-01611410.1186/s13643-017-0521-8Impact of body size, nutrition and socioeconomic position in early life on the epigenome: a systematic review protocolJane Maddock0Wahyu Wulaningsih1Rebecca Hardy2MRC Lifelong Health and Ageing at UCLMRC Lifelong Health and Ageing at UCLMRC Lifelong Health and Ageing at UCLAbstract Background Body size, nutrition and socioeconomic position (SEP) in early life have been associated with a range of later life health outcomes. Epigenetic regulation is one mechanism through which these early life factors may impact later life health. The aim of this review protocol is to outline procedures to document the influence of body size, nutrition and SEP in early life on the epigenome. Methods MEDLINE, Embase and BIOSIS will be systematically searched using pre-defined keywords. Additional studies will be identified through manual searching of reference lists. Two independent researchers will assess the eligibility and quality of each study, with disagreements being resolved through discussion or a third reviewer. Studies will be included if they have epigenetic markers measured either at the same time as, or after, the early life exposure and, have a measure of body size, nutrition or SEP in early life (up to 12 years), are in the English language and are from a sample of community-dwelling participants. Discussion This protocol will be used to collate the evidence for the effect of early life factors on the epigenome. Findings will form a component of a wider research study examining epigenetic responses to exposures in early life and over the life course and its impact on healthy ageing using data from population-based cohort studies. Systematic review registration PROSPERO CRD42016050193http://link.springer.com/article/10.1186/s13643-017-0521-8EpigenomeEpigeneticsEarly lifeBody sizeGrowthNutrition |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jane Maddock Wahyu Wulaningsih Rebecca Hardy |
spellingShingle |
Jane Maddock Wahyu Wulaningsih Rebecca Hardy Impact of body size, nutrition and socioeconomic position in early life on the epigenome: a systematic review protocol Systematic Reviews Epigenome Epigenetics Early life Body size Growth Nutrition |
author_facet |
Jane Maddock Wahyu Wulaningsih Rebecca Hardy |
author_sort |
Jane Maddock |
title |
Impact of body size, nutrition and socioeconomic position in early life on the epigenome: a systematic review protocol |
title_short |
Impact of body size, nutrition and socioeconomic position in early life on the epigenome: a systematic review protocol |
title_full |
Impact of body size, nutrition and socioeconomic position in early life on the epigenome: a systematic review protocol |
title_fullStr |
Impact of body size, nutrition and socioeconomic position in early life on the epigenome: a systematic review protocol |
title_full_unstemmed |
Impact of body size, nutrition and socioeconomic position in early life on the epigenome: a systematic review protocol |
title_sort |
impact of body size, nutrition and socioeconomic position in early life on the epigenome: a systematic review protocol |
publisher |
BMC |
series |
Systematic Reviews |
issn |
2046-4053 |
publishDate |
2017-07-01 |
description |
Abstract Background Body size, nutrition and socioeconomic position (SEP) in early life have been associated with a range of later life health outcomes. Epigenetic regulation is one mechanism through which these early life factors may impact later life health. The aim of this review protocol is to outline procedures to document the influence of body size, nutrition and SEP in early life on the epigenome. Methods MEDLINE, Embase and BIOSIS will be systematically searched using pre-defined keywords. Additional studies will be identified through manual searching of reference lists. Two independent researchers will assess the eligibility and quality of each study, with disagreements being resolved through discussion or a third reviewer. Studies will be included if they have epigenetic markers measured either at the same time as, or after, the early life exposure and, have a measure of body size, nutrition or SEP in early life (up to 12 years), are in the English language and are from a sample of community-dwelling participants. Discussion This protocol will be used to collate the evidence for the effect of early life factors on the epigenome. Findings will form a component of a wider research study examining epigenetic responses to exposures in early life and over the life course and its impact on healthy ageing using data from population-based cohort studies. Systematic review registration PROSPERO CRD42016050193 |
topic |
Epigenome Epigenetics Early life Body size Growth Nutrition |
url |
http://link.springer.com/article/10.1186/s13643-017-0521-8 |
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