Evaluation of Midnight Salivary Cortisol as a Predictor Factor for Common Carotid Arteries Intima Media Thickness in Patients with Clinically Inapparent Adrenal Adenomas

Purpose. The aim of the present study was to investigate the atherosclerotic vascular damage in a consecutive series of patients with AI and to correlate it with MSC. Methods. We studied 32 patients with AI matched with control subjects for age, sex, and cardiovascular risk factors. Either patients...

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Main Authors: Giuseppe Reimondo, Barbara Allasino, Marcella Coletta, Anna Pia, Giulia Peraga, Barbara Zaggia, Chiara Massaglia, Piero Paccotti, Massimo Terzolo
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:International Journal of Endocrinology
Online Access:http://dx.doi.org/10.1155/2015/674734
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spelling doaj-c1c4ebc274e94ab083ed3e5f9f00ac2d2020-11-24T23:04:22ZengHindawi LimitedInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/674734674734Evaluation of Midnight Salivary Cortisol as a Predictor Factor for Common Carotid Arteries Intima Media Thickness in Patients with Clinically Inapparent Adrenal AdenomasGiuseppe Reimondo0Barbara Allasino1Marcella Coletta2Anna Pia3Giulia Peraga4Barbara Zaggia5Chiara Massaglia6Piero Paccotti7Massimo Terzolo8Internal Medicine I, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, 10043 Orbassano, ItalyInternal Medicine I, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, 10043 Orbassano, ItalyInternal Medicine I, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, 10043 Orbassano, ItalyInternal Medicine I, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, 10043 Orbassano, ItalyInternal Medicine I, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, 10043 Orbassano, ItalyInternal Medicine I, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, 10043 Orbassano, ItalyInternal Medicine I, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, 10043 Orbassano, ItalyInternal Medicine I, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, 10043 Orbassano, ItalyInternal Medicine I, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, 10043 Orbassano, ItalyPurpose. The aim of the present study was to investigate the atherosclerotic vascular damage in a consecutive series of patients with AI and to correlate it with MSC. Methods. We studied 32 patients with AI matched with control subjects for age, sex, and cardiovascular risk factors. Either patients or control subjects underwent MSC measurement as outpatients and carotid arteries ultrasound (US) imaging studies. Results. The patients with AI had higher mean carotid artery IMT values and higher MSC levels than control subjects. In a multivariate analysis performed in AI age was the best predictor for IMT. We have stratified patients and control subjects by age (<60 yrs and ≥60 yrs). The patients showed significantly higher MSC levels than controls in both groups, whereas significantly higher IMT values were observed only in older subjects. Conclusions. Patients with AI have signs of accelerated atherosclerosis. Patients older than 60 years seem more susceptible to the possible detrimental effect of subclinical hypercortisolism on cardiovascular system. The MSC levels are not a strong predictor of the accelerated atherosclerosis, but they seem to indicate the subtle but not autonomous cortisol excess that may potentially raise the cardiovascular risk.http://dx.doi.org/10.1155/2015/674734
collection DOAJ
language English
format Article
sources DOAJ
author Giuseppe Reimondo
Barbara Allasino
Marcella Coletta
Anna Pia
Giulia Peraga
Barbara Zaggia
Chiara Massaglia
Piero Paccotti
Massimo Terzolo
spellingShingle Giuseppe Reimondo
Barbara Allasino
Marcella Coletta
Anna Pia
Giulia Peraga
Barbara Zaggia
Chiara Massaglia
Piero Paccotti
Massimo Terzolo
Evaluation of Midnight Salivary Cortisol as a Predictor Factor for Common Carotid Arteries Intima Media Thickness in Patients with Clinically Inapparent Adrenal Adenomas
International Journal of Endocrinology
author_facet Giuseppe Reimondo
Barbara Allasino
Marcella Coletta
Anna Pia
Giulia Peraga
Barbara Zaggia
Chiara Massaglia
Piero Paccotti
Massimo Terzolo
author_sort Giuseppe Reimondo
title Evaluation of Midnight Salivary Cortisol as a Predictor Factor for Common Carotid Arteries Intima Media Thickness in Patients with Clinically Inapparent Adrenal Adenomas
title_short Evaluation of Midnight Salivary Cortisol as a Predictor Factor for Common Carotid Arteries Intima Media Thickness in Patients with Clinically Inapparent Adrenal Adenomas
title_full Evaluation of Midnight Salivary Cortisol as a Predictor Factor for Common Carotid Arteries Intima Media Thickness in Patients with Clinically Inapparent Adrenal Adenomas
title_fullStr Evaluation of Midnight Salivary Cortisol as a Predictor Factor for Common Carotid Arteries Intima Media Thickness in Patients with Clinically Inapparent Adrenal Adenomas
title_full_unstemmed Evaluation of Midnight Salivary Cortisol as a Predictor Factor for Common Carotid Arteries Intima Media Thickness in Patients with Clinically Inapparent Adrenal Adenomas
title_sort evaluation of midnight salivary cortisol as a predictor factor for common carotid arteries intima media thickness in patients with clinically inapparent adrenal adenomas
publisher Hindawi Limited
series International Journal of Endocrinology
issn 1687-8337
1687-8345
publishDate 2015-01-01
description Purpose. The aim of the present study was to investigate the atherosclerotic vascular damage in a consecutive series of patients with AI and to correlate it with MSC. Methods. We studied 32 patients with AI matched with control subjects for age, sex, and cardiovascular risk factors. Either patients or control subjects underwent MSC measurement as outpatients and carotid arteries ultrasound (US) imaging studies. Results. The patients with AI had higher mean carotid artery IMT values and higher MSC levels than control subjects. In a multivariate analysis performed in AI age was the best predictor for IMT. We have stratified patients and control subjects by age (<60 yrs and ≥60 yrs). The patients showed significantly higher MSC levels than controls in both groups, whereas significantly higher IMT values were observed only in older subjects. Conclusions. Patients with AI have signs of accelerated atherosclerosis. Patients older than 60 years seem more susceptible to the possible detrimental effect of subclinical hypercortisolism on cardiovascular system. The MSC levels are not a strong predictor of the accelerated atherosclerosis, but they seem to indicate the subtle but not autonomous cortisol excess that may potentially raise the cardiovascular risk.
url http://dx.doi.org/10.1155/2015/674734
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