Plumbagin Elicits Cell-Specific Cytotoxic Effects and Metabolic Responses in Melanoma Cells

Plumbagin Elicits Cell-Specific Cytotoxic Effects and Metabolic Responses in Melanoma Cells

Melanoma is one of the most malignant skin cancers that require comprehensive therapies, including chemotherapy. A plant-derived drug, plumbagin (PLB), exhibits an anticancer property in several cancers. We compared the cytotoxic and metabolic roles of PLB in A375 and SK-MEL-28 cells, each with diff...

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Bibliographic Details
Main Authors: Haoran Zhang, Aijun Zhang, Anisha A. Gupte, Dale J. Hamilton
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
melanoma
plumbagin
cytotoxic effect
metabolism
mitochondria
reactive oxygen species
Online Access:https://www.mdpi.com/1999-4923/13/5/706

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