Induction of eosinophil apoptosis by the cyclin-dependent kinase inhibitor AT7519 promotes the resolution of eosinophil-dominant allergic inflammation.

Induction of eosinophil apoptosis by the cyclin-dependent kinase inhibitor AT7519 promotes the resolution of eosinophil-dominant allergic inflammation.

Eosinophils not only defend the body against parasitic infection but are also involved in pathological inflammatory allergic diseases such as asthma, allergic rhinitis and contact dermatitis. Clearance of apoptotic eosinophils by macrophages is a key process responsible for driving the resolution of...

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Main Authors: Ana L Alessandri, Rodger Duffin, Andrew E Leitch, Christopher D Lucas, Tara A Sheldrake, David A Dorward, Nik Hirani, Vanessa Pinho, Lirlândia Pires de Sousa, Mauro M Teixeira, John F Lyons, Christopher Haslett, Adriano G Rossi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3184151?pdf=render

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